Korean Journal of Biological Psychiatry (생물정신의학)

The Korean Society of Biological Psychiatry (대한생물정신의학회)
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The Impact of Choline Acetyltransferase Polymorphism on the Expression of Mild Cognitive Impairment

Choline Acetyltransferase 유전자 다형성이 경도인지손상 발현에 미치는 영향

  • Lee, Jung-Jae (Department of Psychiatry, Kyungpook National University Hospital) ;
  • Park, Joon-Hyuk (Department of Psychiatry, Jeju National University Hospital) ;
  • Lee, Seok-Bum (Department of Psychiatry, Dankook University Hospital) ;
  • Huh, Yoon-Seok (Department of Neuropsychiatry, Seoul National University Bundang Hospital) ;
  • Kim, Tae-Hui (Department of Neuropsychiatry, Seoul National University Bundang Hospital) ;
  • Youn, Jong-Chul (Department of Neuropsychiatry, Kyunggi Provincial Hospital for the Elderly) ;
  • Jhoo, Jin-Hyeong (Department of Neuropsychiatry, Kangwon National University Hospital) ;
  • Lee, Dong-Young (Department of Psychiatry, Seoul National University Hospital) ;
  • Park, Koung-Un (Department of Laboratory Medicine, Seoul National University Bundang Hospital) ;
  • Kim, Ki-Woong (Department of Neuropsychiatry, Seoul National University Bundang Hospital)
  • 이정재 (경북대학교병원 정신과학교실) ;
  • 박준혁 (제주대학교병원 정신과학교실) ;
  • 이석범 (단국대학교병원 정신과학교실) ;
  • 허윤석 (분당서울대학교병원 신경정신과학교실) ;
  • 김태희 (분당서울대학교병원 신경정신과학교실) ;
  • 윤종철 (경기도노인전문병원 신경정신과) ;
  • 주진형 (강원대학교병원 신경과학교실) ;
  • 이동영 (서울대학교병원 정신과학교실) ;
  • 박경운 (분당서울대학교병원 진단검사의학과학교실) ;
  • 김기웅 (분당서울대학교병원 신경정신과학교실)
  • Received : 2010.10.18
  • Accepted : 2010.10.26
  • Published : 2010.11.30
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Abstract

Objectives : The potential association between choline acetyltransferase(CHAT) polymorphism and the risk of mild cognitive impairment(MCI) has not been investigated in Korea. We examined the main effect of CHAT polymorphism and its interaction with apolipoprotein E(APOE) polymorphism in the development of MCI in elderly Korean sample. Methods : We analyzed CHAT 2384G > A polymorphism and APOE polymorphism among 149 MCI subjects with MCI and 298 normal controls. We tested the association between MCI and CHAT A allele status using a logistic regression model. In addition, we employed generalized multifactor dimensionality reduction(GMDR) to investigate the interaction between CHAT and APOE with regard to the risk of MCI. Results : The CHAT A allele was associated with AD risk(OR = 1.59, 95% CI = 1.02-2.48, p = 0.042). No significant gene-gene interaction between CHAT and APOE was found in GMDR method(testing balanced accuracy = 0.540, p = 0.055). Conclusion : The CHAT A allele was associated with MCI risk in the Korean elderly. Its interaction with the APOE ${\varepsilon}4$ allele was not significant with regard to the development of MCI.

Keywords

References

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