대한본초학회지 (The Korea Journal of Herbology)

  • 제25권3호
  • /
  • Pages.81-90
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  • 2010
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  • 1229-1765(pISSN)
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  • 2288-7199(eISSN)
대한본초학회 (The Korea Association of Herbology)
권호 표지
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장구채 전초와 맥람채 종자의 고지혈증(高脂血症)에 대한 효능 비교 연구

Comparative Studies on the Hyperlipidemia of Melandrii Herba and Vaccariae Semen

  • 이만희 (경원대학교 한의과대학 본초학교실) ;
  • 한효상 (경원대학교 한의과대학 본초학교실) ;
  • 이영종 (경원대학교 한의과대학 본초학교실)
  • Lee, Man-Hee (Dept. of Herbology, College of Oriental Medicine, Kyungwon University) ;
  • Han, Hyo-Sang (Dept. of Herbology, College of Oriental Medicine, Kyungwon University) ;
  • Lee, Young-Jong (Dept. of Herbology, College of Oriental Medicine, Kyungwon University)
  • 투고 : 2010.08.10
  • 심사 : 2010.09.13
  • 발행 : 2010.09.30
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초록

Objectives : The present study purposed to compare the effects of Melandrii Herba and Vaccariae Semen, which are used as Wang-Bul-Yu-Haeng(王不留行) with vasodilatory effect in Korea and China, respectively, on hyperlipidemia. Methods : We applied the water extract of Melandrii Herba and Vaccariae Semen to rats with hyperlipidemia induced by high-cholesterol diet and high-fructose diet and evaluated their effects. Results : While Vaccariae Semen had significant effect on the reduction of the levels of total cholesterol, LDL-cholesterol, free cholesterol, and the activation of ALT, the application of Melandrii Herba had no significant effect on the levels of total cholesterol, LDL-cholesterol, free cholesterol, neutral fat, and free fatty acid, and the activation of AST. For the rats with hypertriglyceridemia, Vaccariae Semen reduced the levels of neutral fat and total cholesterol, but did not significantly reduce the level of free fatty acid and the activation of AST and ALT. The application of Melandrii Herba did not have any significant effect on the levels of neutral fat, total cholesterol, and free fatty acid, and the activation of AST and ALT, but it increased the level of HDL cholesterol. Conclusion : Vaccariae Semen showed a possibility as a remedy for hyperlipidemia, but Melandrii Herba did not show any significant effect. Thus, based on such a difference in remedial effect between Melandrii Herba and Vaccariae Semen, they need to be distinguished in clinical application.

키워드

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피인용 문헌

  1. HPLC 를 이용한 가는장구채 추출물의 Isoscoparin 분석법 개발 vol.47, pp.1, 2010, https://doi.org/10.15230/scsk.2021.47.1.57