Journal of Veterinary Clinics (한국임상수의학회지)

The Korean Society of Veterinary Clinics (한국임상수의학회)
권호 표지

Renal Adenocarcinoma in a California Sea Lion (Zalophus Californianus)

캘리포니아바다사자(Zalophus Californianus)에서 간과 비장전이를 보인 악성신장종양 예

  • Kim, Sun-A (College of Veterinary Medicine, Seoul National University) ;
  • You, Mi-Hyeon (College of Veterinary Medicine, Seoul National University) ;
  • Eo, Kyung-Yeon (Seoul Zoo) ;
  • Kim, Dae-Yong (College of Veterinary Medicine, Seoul National University) ;
  • Shin, Nam-Shik (College of Veterinary Medicine, Seoul National University)
  • Accepted : 2010.05.25
  • Published : 2010.06.30
Download PDF
⟨ Previous Next ⟩

Abstract

A 25-year-old female California sea lion (Zalophus californianus) died after a history of depression, loss of appetite, weakness and weight loss. At necropsy, multifocal to coalescing, tan to white, firm nodules, ranging from 0.5 to 3 cm in diameter were observed throughout both kidneys. Renal adenocarcinoma metastasis to the liver, spleen and small intestine was diagnosed based on gross and histopathological findings. To the best our knowledge, this is the first reported case in Korea, and understanding this case will support management and diagnosis of future cases of renal adenocarcinoma in California sea lions.

25년령의 암컷 캘리포니아 바다사자(Zalophus californianus)가 고령으로 인하여 분리 사육되고 있었다. 침울, 식욕부진, 쇠약, 체중감소 등의 임상증상을 보인 후 폐사하였고, 부검을 실시하였다. 육안적으로 양측 신장은 창백하고 직경 0.5-3 cm의 종양 결절이 다발성으로 관찰되었다. 간과 비장, 소장에서도 한계가 명료하고 크기가 다양하며 단단한 전이성 종양 결절이 다발성으로 존재하고 있었다. 본 예는 육안 및 병리조직학적 소견을 근거로 신장과 비장, 소장의 전이를 동반한 신장세포암종으로 진단할 수 있었다. 국내 캘리포니아 바다사자에서의 신장암의 보고는 드물며 향후 임상적으로 바다사자의 진료와 진단에 도움이 되고자 본 논문을 발표하는 바이다.

Keywords

References

  1. Brown RJ, Smith AW, Morejohn GV, DeLong RL. Metastatic adenocarcinoma in two California sea lions, Zalophus c. californianus. J Wildl Dis 1980; 16: 261-266. https://doi.org/10.7589/0090-3558-16.2.261
  2. Buckles EL, Lowenstine LJ, Funke C, Vittore RK, Wong HN, St Leger JA, Greig DJ, Duerr RS, Gulland FM, Stott JL. Otarine Herpesvirus-1, not papillomavirus, is associated with endemic tumours in California sea lions (Zalophus californianus). J Comp Pathol 2006; 135: 183-189. https://doi.org/10.1016/j.jcpa.2006.06.007
  3. Johnson S, Lowenstine L, Gulland F, Jang S, Imai D, Almy F, Delong R, Gardner I. Aerobic bacterial flora of the vagina and prepuce of California sea lions (Zalophus californianus) and investigation of associations with urogenital carcinoma. Vet Microbiol 2006; 114: 94-103. https://doi.org/10.1016/j.vetmic.2005.11.045
  4. Joseph BE, Cornell LH, Migaki G. Metastatic squamous cell carcinoma in a beached California sea lion (Zalophus californianus). J Wildl Dis 1986; 22: 281-283. https://doi.org/10.7589/0090-3558-22.2.281
  5. King DP, Hure MC, Goldstein T, Aldridge BM, Gulland FM, Saliki JT, Buckles EL, Lowenstine LJ, Stott JL. Otarine herpesvirus-1: a novel gammaherpesvirus associated with urogenital carcinoma in California sea lions (Zalophus californianus). Vet Microbiol 2002; 86: 131-137. https://doi.org/10.1016/S0378-1135(01)00497-7
  6. McAllose D, Newton AL. Wildlife cancer: a conservation perspective. Nat Rev Cancer 2009; 9: 517-26. https://doi.org/10.1038/nrc2665
  7. McGavin M, Carlton W, Zachary J. Thomson's special veterinary pathology. 3rd ed. St. Louis: Mosby, 2001; 270: 376-377.
  8. McGavin M, Zachary J. Pathologic basis of Veterinary disease. 4th ed. St. Louis: Mosby Elsevier, 2007; 677-679.
  9. Meuten D. Tumors in domestic animals. 4th ed. Ames: A Blackwell publishing company, 2002; 509-516.
  10. Newman SJ, Smith SA. Marine mammal neoplasia: a review. Vet Pathol 2006; 43: 865-880. https://doi.org/10.1354/vp.43-6-865
  11. Nowak R. Walker's Mammals of the world. 6th ed. Baltimore: The Johns Hopkins university press, 1999; 852-855.
  12. Wallach J, Boever W. Disease of exotic animals. Philadelphia: WB Saunders Co., 1983; 727-728.
  13. Ylitalo GM, Stein JE, Hom T, Johnson LL, Tilbury KL, Hall AJ, Rowles T, Greig D, Lowenstine LJ, Gulland FM. The role of organochlorines in cancer-associated mortality in California sea lions (Zalophus californianus). Mar Pollut Bull 2005; 50: 30-39. https://doi.org/10.1016/j.marpolbul.2004.08.005
  14. You MH, Bae IH, Jee H, Yoo MJ, Shin NS, Kim DY. Hemangiosarcoma in a South American sea lion (Otaria byronia). J Zoo Wildl Med 2008; 39: 118-120. https://doi.org/10.1638/2007-0019.1