Journal of Veterinary Clinics (한국임상수의학회지)

The Korean Society of Veterinary Clinics (한국임상수의학회)
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Blood Electrolytes and Metabolites in Rat Model of Acute Metabolic and Respiratory Alkalosis

흰쥐 급성 대사성 알칼리증과 호흡성 알칼리증 모델에서 혈액 전해질 및 대사산물

  • Kim, Shang-Jin (College of Veterinary Medicine, Chonbuk National University) ;
  • Lee, Mun-Young (College of Veterinary Medicine, Chonbuk National University) ;
  • Kim, Jin-Shang (Korean Zoonoses Research Institute, Chonbuk National University) ;
  • Kang, Hyung-Sub (Korean Zoonoses Research Institute, Chonbuk National University)
  • 김상진 (전북대학교 수의과대학) ;
  • 이문영 (전북대학교 수의과대학) ;
  • 김진상 (전북대학교 인수공통전염병연구소) ;
  • 강형섭 (전북대학교 인수공통전염병연구소)
  • Accepted : 2010.06.15
  • Published : 2010.06.30
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Abstract

The development of blood ionic changes could be precipitated in acid-base disorder and subsequent treatment. As technology for detecting circulating ionized $Mg^{2+}$ (the most interesting form with respect to physiological and biological properties) is now available in veterinary clinical medicine. This present study investigated the changes of whole blood ionized $Mg^{2+}$ correlated with acute metabolic and respiratory alkalosis in rodent model. Metabolic alkalosis was induced by intravenous infusion with $NaHCO_3$ and mechanical hyperventilation was applied for respiratory alkalosis. We founded that the blood ionized $Mg^{2+}$ could be reversibly decreased by the $NaHCO_3$-induced acute metabolic alkalosis but irreversibly increased by the mechanical hyperventilation-induced respiratory acidosis and respiratory acidosis. We suggested that the potential change in blood suggested that the potential change in blood ionized $Mg^{2+}$ should be counted in treatment of acid-base disorders.

산염기 불균형과 수반되는 치료과정에서 혈액 이온들은 변동되어 질 수 있다. 생리적 그리고 생물학적 활성을 가진 순환 이온화 $Mg^{2+}$ 측정이 수의 임상분야에도 적용되고 있다. 실험동물모델에서 급성 대사성 알칼리증 및 호흡성 알칼리증에 수반하는 혈액 이온화 $Mg^{2+}$ 변동을 관찰하였다. 대사성 알칼리증은 $NaHCO_3$ 정맥투여로 그리고 호흡성 알칼리증은 과호흡에 의해 유도하였다. 혈액 이온화 $Mg^{2+}$은 $NaHCO_3$에 의해 유도된 대사성 알칼리증에서는 가역적인 감소를 보인 반면, 과호흡에 의해 유도된 호흡성 알칼리증에서는 비가역적인 증가를 보였다. 따라서 산염기 불균형 치료에 있어 혈액 이온화 $Mg^{2+}$의 잠재적 변동 가능성을 고려하여야 한다고 판단된다.

Keywords

References

  1. Berlin D, Aroch I. Concentrations of ionized and total magnesium and calcium in healthy horses: effects of age, pregnancy, lactation, pH and sample type. Vet J 2009; 181: 305-311. https://doi.org/10.1016/j.tvjl.2008.03.014
  2. Bleul UT, Schwantag SC, Kähn WK. Effects of hypertonic sodium bicarbonate solution on electrolyte concentrations and enzyme activities in newborn calves with respiratory and metabolic acidosis. Am J Vet Res 2007; 68: 850-857. https://doi.org/10.2460/ajvr.68.8.850
  3. Chew DJ, Leonard M, Muir WW 3rd. Effect of sodium bicarbonate infusion on serum osmolality, electrolyte concentrations, and blood gas tensions in cats. Am J Vet Res 1991; 52: 12-17.
  4. Gunnerson KJ. Clinical review: the meaning of acid-base abnormalities in the intensive care unit part I- epidemiology. Crit Care 2005; 9: 508-516. https://doi.org/10.1186/cc3796
  5. Hafen G, Laux-End R, Truttmann AC, Schibler A, McGuigan JA, Peheim E, Bianchetti MG. Plasma ionized magnesium during acute hyperventilation in humans. Clin Sci 1996; 91: 347-351. https://doi.org/10.1042/cs0910347
  6. Hopper K, Rezende ML, Haskins SC. Assessment of the effect of dilution of blood samples with sodium heparin on blood gas, electrolyte, and lactate measurements in dogs. Am J Vet Res 2005; 66: 656-660. https://doi.org/10.2460/ajvr.2005.66.656
  7. Levin M, Winaver J. Effects of systemic alkalosis on urinary magnesium excretion in the rat. Miner Electrolyte Metab 1989; 15: 214-220.
  8. Lindinger MI, Heigenhauser GJ, Spriet LL. Effects of alkalosis on muscle ions at rest and with intense exercise. Can J Physiol Pharmacol 1990; 68: 820-829. https://doi.org/10.1139/y90-125
  9. Maguire ME, Cowan JA. Magnesium chemistry and biochemistry. BioMetals 2002; 15: 203-210. https://doi.org/10.1023/A:1016058229972
  10. Morgan TJ. The meaning of acid-base abnormalities in the intensive care unit: part III -- effects of fluid administration. Crit Care 2005; 9: 204-211. https://doi.org/10.1186/cc3267
  11. Ozaki J, Tanimoto N, Kuse H, Hori M. Comparison of arterial blood gases and acid-base balance in young and aged beagle dogs, with regard to postprandial alkaline tide. J Toxicol Sci 2000; 25: 205-211. https://doi.org/10.2131/jts.25.3_205
  12. Proksch JW, Gentry WB, Owens SM. Pharmacokinetic mechanisms for obtaining high renal coelimination of phencyclidine and a monoclonal antiphencyclidine antigen-binding fragment of immunoglobulin G in the rat. J Pharmacol Exp Ther 1998; 287: 616-624.
  13. Quamme GA. Renal magnesium handling: new insights in understanding old problems. Kidney Int 1997; 52: 1180-1195. https://doi.org/10.1038/ki.1997.443
  14. Roy DR, Blouch KL, Jamison RL. Effects of acute acid-base disturbances on renal tubule reabsorption of magnesium in the rat. Am J Physiol 1982; 243: 197-203.
  15. Santella RN, Maddox DA, Gennari FJ, Delivery dependence of early proximal bicarbonate reabsorption in the rat in respiratory acidosis and alkalosis. J Clin Invest 1991; 7: 631- 638.
  16. Saris NE, Mervaala E, Karppanen H, Khawaja JA, Lewenstam A. Magnesium. An update on physiological, clinical and analytical aspects. Clin Chim Acta 2000; 294: 1-26. https://doi.org/10.1016/S0009-8981(99)00258-2
  17. Unterer S, Gerber B, Glaus TM, Hassig M, Reusch CE. Evaluation of an electrolyte analyser for measurement of concentrations of ionized calcium and magnesium in cats. Vet Res Commun 2005; 29: 647-659. https://doi.org/10.1007/s11259-005-3301-1
  18. Webster MJ, Webster MN, Crawford RE, Gladden LB. Effect of sodium bicarbonate ingestion on exhaustive resistance exercise performance. Med Sci Sports Exerc 1993; 25: 960-965.
  19. Weiss D, Burger D, Weishaupt MA, Fakler A, Spichiger UE, Giese L, Liesegang A, Wanner M, Riond JL. Effects of a 61.7 km ride on magnesium and calcium homeostasis in well trained endurance horses. J Equi Vet Sci 2002; 22: 77-83. https://doi.org/10.1016/S0737-0806(02)70093-2
  20. Webster MJ, Webster MN, Crawford RE, Gladden LB. Effect of sodium bicarbonate ingestion on exhaustive resistance exercise performance. Med Sci Sports Exerc 1993; 25: 960-965.
  21. Zaidenberg G, Mimouni FB, Dollberg S. EFFect of bicarbonate on neonatal serum ionized magnesium in vitro. Magnes Res 2004; 17: 90-93.