생약학회지 (Korean Journal of Pharmacognosy)

  • 제41권3호
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  • Pages.227-231
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  • 2010
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  • 0253-3073(pISSN)
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  • 2288-9299(eISSN)
한국생약학회 (The Korean Society of Pharmacognosy)
권호 표지

생약의 Protein Tyrosine Phosphatase 1B 저해활성 검색

Screening of Medicinal Herbs for Inhibitory Activity against Protein Tyrosine Phosphatase 1B

  • 이우정 (한국과학기술연구원 강릉분원) ;
  • 김수남 (한국과학기술연구원 강릉분원) ;
  • 윤구 (한국과학기술연구원 강릉분원)
  • 투고 : 2010.08.06
  • 심사 : 2010.08.26
  • 발행 : 2010.09.30
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초록

Protein tyrosine phosphatase 1B (PTP1B) is predicted to be therapeutic target in treatment of type 2 diabetes and obesity. Thus, in order to search for PTP1B inhibitors, we screened the inhibitory activity of PTP1B in the water extracts of 84 medicinal herbs. Among them, the extracts of Pini Folium, Magnoliae Cortex, Artemisiae asiaticae Herba, Schizonepetae Herba, Menthae Herba, Mume Fructus, Cimicifugae Rhizoma, and Amomi Cardamomi Fructus showed relatively significant (58-68%) inhibitory activity against PTP1B. Especially, the methylene chloride fraction of the methanol extract of Menthae Herba (81% inhibition at 30 ${\mu}g$/ml) showed more potent inhibitory activity against PTP1B than others.

키워드

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