Korean Journal of Pharmacognosy (생약학회지)

The Korean Society of Pharmacognosy (한국생약학회)
권호 표지

The Comparison of Constituents Distributed in the Root of Angelica dahurica

구릿대 뿌리의 부위별 성분 비교

  • Youn, Ui-Joung (College of Pharmacy, Chungnam National University) ;
  • Yoo, Jae-Kuk (Han Kook Shin Yak) ;
  • Chen, Quan-Cheng (College of Pharmacy, Chungnam National University) ;
  • Lee, Ik-Soo (College of Pharmacy, Chungnam National University) ;
  • Na, Min-Kyun (College of Pharmacy, Yeungnam University) ;
  • Min, Byung-Sun (College of Pharmacy, Catholic University of Daegu) ;
  • Jung, Hyun-Ju (Department of Oriental Pharmacy and Wonkwang-Oriental Medicines Research Institute, Wonkwang University) ;
  • Seo, Eun-Kyoung (The Center for Cell Signaling & Drug Discovery Research, College of Pharmacy, Ewha Womans University) ;
  • Bae, Ki-Hwan (College of Pharmacy, Chungnam National University)
  • 윤의중 (충남대학교 약학대학) ;
  • 유재국 ((주)한국신약) ;
  • 진전성 (충남대학교 약학대학) ;
  • 이익수 (충남대학교 약학대학) ;
  • 나민균 (영남대학교 약학대학) ;
  • 민병선 (대구가톨릭대학교 약학대학) ;
  • 정현주 (원광대학교 약학대학 한약학과 및 원광한약연구소) ;
  • 서은경 (이화여자대학교 약학대학) ;
  • 배기환 (충남대학교 약학대학)
  • Received : 2010.08.04
  • Accepted : 2010.08.23
  • Published : 2010.09.30
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Abstract

In this study, we analyzed and quantified the amounts of bioactive phenolic constituents, xanthotoxin (1), oxypeucedanin (2), and imperatorin (3) in each part of the root of Angelica dahurica by HPLC, which validated by ICH guide lines comparing the linearity, intra day precision, inter-day precision. As a result, the amount of imperatorin 2.96% in the rootlet was two fold higher than that of the main root 1.32%. On the other hand, the amounts of xanthotoxin and oxypeucedanin in the rootlet showed similar to those of main root. In addition, the cortex of root is more plentiful of three consitituents (0.66%, 0.53%, and 1.85%) than those of xylem (0.29%, 0.05%, and 0.07%). These results show that the rootlet and cortex contain a large amount of bioactive phenolic constituent including xanthotoxin, oxypeucedanin, and imperatorin than other parts of the root.

Keywords

References

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