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Agonistic Anti-CD137 Monoclonal Antibody Treatment Induces CD11b+Gr-1+ Myeloid-derived Suppressor Cells

  • Lee, Jung-Mi (Laboratory of Immunology, Institute of Pharmaceutical Sciences, College of Pharmacy, Seoul National University) ;
  • Seo, Jeong-Hwan (Laboratory of Immunology, Institute of Pharmaceutical Sciences, College of Pharmacy, Seoul National University) ;
  • Kim, Yeon-Jeong (Laboratory of Immunology, Institute of Pharmaceutical Sciences, College of Pharmacy, Seoul National University) ;
  • Kim, Yun-Sun (Laboratory of Immunology, Institute of Pharmaceutical Sciences, College of Pharmacy, Seoul National University) ;
  • Ko, Hyun-Jeong (Laboratory of Immunology, Institute of Pharmaceutical Sciences, College of Pharmacy, Seoul National University) ;
  • Kang, Chang-Yuil (Laboratory of Immunology, Institute of Pharmaceutical Sciences, College of Pharmacy, Seoul National University)
  • Received : 2010.05.25
  • Accepted : 2010.06.07
  • Published : 2010.06.30
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Abstract

CD137 (4-1BB/tnfrsf9) has been shown to co-stimulate T cells. However, agonistic anti-CD137 monoclonal antibody (mAb) treatment can suppress $CD4^+$ T cells, ameliorating autoimmune diseases, whereas it induces activation of $CD8^+$ T cells, resulting in diverse therapeutic activity in cancer, viral infection. To investigate the CD137-mediated T cell suppression mechanism, we examined whether anti-CD137 mAb treatment could affect $CD11b^+Gr-1^+$ myeloid-derived suppressor cells (MDSCs). Intriguingly, anti-CD137 mAb injection significantly increased $CD11b^+Gr-1^+$ cells, peaking at days 5 to 10 and continuing for at least 25 days. Furthermore, this cell population could suppress both $CD8^+$ T cells and $CD4^+$ T cells. Thus, this study demonstrated that, for the first time, anti-CD137 mAb treatment could induce $CD11b^+Gr-1^+$ MDSCs under normal conditions, suggesting a possible relationship between myeloid cell induction and CD137-mediated immune suppression.

Keywords

References

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