Bulletin of the Korean Chemical Society

Korean Chemical Society (대한화학회)
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Effect of Dextran Gel on Preparation of Nano-liposomes Loaded with Ginkgolide

  • Tong, Yuan (School of Life Science, Anhui University) ;
  • Chen, Yan (School of Life Science, Anhui University) ;
  • Pan, Jian (Engineering Research Center of Bio-Process, Hefei University of Technology, Ministry of Education) ;
  • Huang, Li (School of Life Science, Anhui University) ;
  • Wang, Ruijun (School of Life Science, Anhui University)
  • Received : 2010.03.23
  • Accepted : 2010.07.22
  • Published : 2010.09.20
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Abstract

The objective of this paper was to investigate the effect of dextran gel on preparation of nano-liposomes loaded with ginkgolide. During preparation, Sephadex G75, G50 and G25 were added in the aqueous phase respectively. From the experiment, nano-liposomes prepared by dextran gels were found spherical and smooth. The result indicated that aperture of dextran gels were narrower, particle size of nano-liposomes was smaller (207.13 ~ 89.16 nm) and zeta potential was greater (-36.2 ~ -29.5 mV) in more negative. The study also revealed that differences of the entrapment efficiency and drug loading among the three types of nano-liposomes were not significant. In vitro drug release test demonstrated that nano-liposomes had a better controlled release. To conclude, by using dextran gel in the preparation of nano-liposome loaded with ginkgolide, the particle size could be effectively controlled and the drug stability could be improved.

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