Bulletin of the Korean Chemical Society

Korean Chemical Society (대한화학회)
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Synthesis and Antiviral Evaluation of 1'-Branched-5'-Norcarbocyclic Adenosine Phosphonic Acid Analogues

  • Oh, Chang-Hyun (Medicinal Chemistry Research Center, Korea Institute of Science and Technology) ;
  • Yoo, Kyung-Ho (Medicinal Chemistry Research Center, Korea Institute of Science and Technology) ;
  • Hong, Joon-Hee (BK21 Project Team, College of Pharmacy, Chosun University)
  • Received : 2010.06.17
  • Accepted : 2010.07.07
  • Published : 2010.09.20
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Abstract

Novel 1'-methyl-5'-norcarbocyclic adenosine phosphonic acid analogues were synthesized using an acyclic stereoselective route from commercially available 3,3-diethoxy-propan-1-ol 4. The synthesized nucleoside phosphonate 19 and phosphonic acid 21 were subjected to antiviral screening against various viruses.

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References

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