Bulletin of the Korean Chemical Society

Korean Chemical Society (대한화학회)
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Synthesis, Characterization and Biological Activities of Novel (E)-3-(1-(Alkyloxyamino)ethylidene)-1-alkylpyrrolidine-2,4-dione Derivatives

  • Zhu, Zhao-Yong (Department of Chemistry, College of Science, Nanjing Agricultural University) ;
  • Shi, Qing-Ming (Department of Chemistry, College of Science, Nanjing Agricultural University) ;
  • Han, Bao-Feng (Department of Chemistry, College of Science, Nanjing Agricultural University) ;
  • Wang, Xian-Feng (Department of Chemistry, College of Science, Nanjing Agricultural University) ;
  • Qiang, Sheng (College of Life Science, Nanjing Agricultural University) ;
  • Yang, Chun-Long (Department of Chemistry, College of Science, Nanjing Agricultural University)
  • Received : 2010.05.24
  • Accepted : 2010.07.04
  • Published : 2010.09.20
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Abstract

Twenty novel tetramic acid derivatives (E)-3-(1-(alkyloxyamino)ethylidene)-1-alkylpyrrolidine-2,4-diones were synthesized by the reaction of 3-(1-hydroxyethylidene)pyrrolidine-2,4-diones with O-alkyl hydroxylamines. The title compounds were confirmed by IR, $^1H$ NMR, MS and elemental analysis. The structure of compound 6r was further verified by X-ray diffraction crystallography. The bioassays showed that most of the title compounds exhibited noticeable herbicidal and fungicidal activities.

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References

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