The Journal of Internal Korean Medicine (대한한방내과학회지)

The Society of Internal Korean Medicine (대한한방내과학회)
권호 표지

Effects of Yijintang-gamibang on Reflux Esophagitis Induced by Pylorus and Forestomach Ligation in Rat

역류성식도염 유발 흰쥐에 대한 이진탕가미방(二陳湯加味方)의 효과

  • Kim, Hee-Jun (Dept. of Oriental Internal Medicine, College of Oriental Medicine, Dae-Gu Hanny University) ;
  • Lim, So-Yeon (Dept. of Oriental Internal Medicine, College of Oriental Medicine, Dae-Gu Hanny University) ;
  • Kwak, Min-A (Dept. of Oriental Internal Medicine, College of Oriental Medicine, Dae-Gu Hanny University) ;
  • Kim, Dae-Jun (Dept. of Oriental Internal Medicine, College of Oriental Medicine, Dae-Gu Hanny University) ;
  • Byun, Joon-Seok (Dept. of Oriental Internal Medicine, College of Oriental Medicine, Dae-Gu Hanny University)
  • 김희준 (대구한의대학교 한의과대학 비계내과학교실) ;
  • 임소연 (대구한의대학교 한의과대학 비계내과학교실) ;
  • 곽민아 (대구한의대학교 한의과대학 비계내과학교실) ;
  • 김대준 (대구한의대학교 한의과대학 비계내과학교실) ;
  • 변준석 (대구한의대학교 한의과대학 비계내과학교실)
  • Published : 2010.03.31
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Abstract

Purpose : The object of this study was to observe the suppressive effects of Yijintang-gamibang (YJGMB), Yijintang with Atractylodis Rhizoma, Massa Medicata Fermentata, Hordei Fructus Germiniatus, and Coptidis Rhizoma. YJGMB has been traditionally used in Korean medicine for treating various digestive diseases. We tested it on the rat reflux esophagitis (RE) induced by pylorus and forestomach ligation in rats as compared with omeprazole, a well-known proton pump inhibitor. Method : Three different dosages of YJGMB 200, 100 and 50mg/kg, were orally pretreated once a day for 28 days before pylorus and forestomach ligation. Seven groups, each of 8 rats per group were used in the study. Six hours after pylorus and forestomach ligation, changes of the stomach and esophagus lesion areas, gastric volumes, acid and pepsin outputs, invasive lesion percentages, fundic mucosa and total thicknesses were measured as histomorphometry. The results were compared with omeprazole, antioxidant and proton pump inhibitor, and 30 and 10mg/kg treated groups in which the effects on RE were already confirmed. Results : As results of pylorus and forestomach ligation, marked increases of esophageal and gastric mucosa lesion areas, gastric volumes, acid outputs, pepsin outputs were observed with histopathological changes of RE, such as hemorrhages, ulcerative lesions and edematous changes on the fundic mucosa. However, these pylorus and forestomach ligation-induced RE were dose-dependently inhibited by treatment of 200, 100 and 50mg/kg of YJGMB. YJGMB 200mg/kg showed similar protective effects as compared with 30mg/kg of omeprazole in the present study, and more favorable effects were observed in 50mg/kg of YJGMB treated rats as compared with omeprazole 10mg/kg in the present study. Conclusion : The results obtained in this study suggest that YJGMB has favorable protective effects on the RE induced by pylorus and forestomach ligation. Therefore, it is expected that YJGMB will also show favorable effects on RE corresponding well to the suggestion of traditional Korean medicine. However, more detailed mechanism studies should be conducted in future with the screening of the biological active chemical compounds in herbs.

Keywords

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