대한한방내과학회지 (The Journal of Internal Korean Medicine)

대한한방내과학회 (The Society of Internal Korean Medicine)
권호 표지

한.양방 입원 환자의 비정상 간기능 검사 발생률 비교

Comparison of Incidence of Abnormal Liver Function Test between Inpatients Who Take Traditional Korean versus Conventional Medicine

  • 한창우 (자생한방병원 한방내과)
  • Han, Chang-Woo (Dept. of Oriental Internal Medicine, Jaseng Hospital of Oriental Medicine)
  • 발행 : 2010.03.31
PDF 다운로드
⟨ 이전 논문 다음 논문 ⟩

초록

Herbal hepatotoxicity is a one of the most often encountered controversial issues in medical society. Some believe herbs are totally safe while others regard treatment with herbs as a very common cause of hepatotoxicity. But there are no comparative clinical hepatotoxicity studies between herbal and conventional medicines. We investigated incidence of patients with abnormal liver function who were treated with herbal or conventional medicine at Dongguk University International Hospital. Each group consisted of 300 patients, who were admitted for longer than 30 days during the year 2008. We compared albumin, total bilirubin, AST (aspartate aminotransferase), and ALT (alanine aminotransferase) levels, and excludes patients who had abnormal liver function test or liver-related disease when admitted. As a result, incidence of total bilirubin, AST, and ALT elevation in the CT (conventional treatment) group was more frequent than in the TKM (traditional Korean medicine) group (p<0.05) during admission. Albumin level also decreased more frequently in the CT group than in the TKM group (p<0.05). According to these results, herbal medicine is not more hepatotoxic than conventional medicine, and not a main cause of liver injury in inpatients.

키워드

참고문헌

  1. Fauci AS, Braunwald E, Kasper DL, Hauser SL, Longo DL, Jameson JL, et al. Harrison's principles of internal medicine. 17th edition. USA: McGraw-Hill; 2008, p. 1949-1955.
  2. Jang IS, Yang CS, Lee SD, Han CH. A review on herbal medicinal products associated with toxic events in Korea: mistake and true. Korean J Orient Int Med. 2007;28(spr):67-75.
  3. Lee E, Park BW, Hea GJ, Ko H. A study on the side effects and toxicity of herbal medicine. Korean J Orient Int Med. 2002;23(2):222-227.
  4. Larrey D. Hepatotoxicity of herbal remedies. J Hepatol. 1997;26(Suppl 1):47-51.
  5. Chavez ML, Jordan MA, Chavez PI. Evidence -based drug-herbal interactions. Life Sci. 2006; 78(18):2146-2157. https://doi.org/10.1016/j.lfs.2005.12.009
  6. Seeff LB. Herbal hepatotoxicity. Clin Liver Dis. 2007;11(3):577-596. https://doi.org/10.1016/j.cld.2007.06.005
  7. Yun YJ, Shin BC, Lee MS, Cho SI, Park JH, Lee HJ. Systemic review of the cause of drug-induced liver injuries in Korean literature. J Korean Oriental Med. 2009;30(2):30-45.
  8. Ziser A, Plevak DJ, Wiesner RH, Rakela J, Offord KP, Brown DL. Morbidity and mortality in cirrhotic patients undergoing anesthesia and surgery. Anesthesiology. 1999;90:42-53. https://doi.org/10.1097/00000542-199901000-00008
  9. Kang SH, Kim JL, Jeong KH, Ko KH, Ko PG, Hwang SW, et al. Clinical characteristics of 159 cases of acute toxic hepatitis. Korean J Hepatol. 2008;14(4):483-492. https://doi.org/10.3350/kjhep.2008.14.4.483
  10. Rhee SH, Park JS, Yeo HS, Choi YK, Jun CY, Park CH, et al. Relationship between herb-medine and liver damage. Korean J Orient Int Med. 2006;27(3):572-578.
  11. Paeck EK, Park JH, Yoon JY, Jeong SK, Lee HJ, Lim JS, et al. Influence of taking medicine for a period of time on the liver function and improvement of the developmental disordered children. Korean J Orient Physiol Pathol. 2006;20(2):494-497.
  12. Pittler MH, Ernst E. Systemic review: hepatotoxic events associated with herbal medicinal products. Aliment Pharmacol Ther. 2003;18(5):451-471. https://doi.org/10.1046/j.1365-2036.2003.01689.x
  13. Chun WJ, Yoon BG, Kim NI, Lee G, Yang CH, Lee CW, et al. A clinical study of patients with acute liver injury caused by herbal medication in Gyeongju area. Korean J Med. 2002;63(2):141-150.
  14. Ahn BM. Herbal preparation-induced liver injury. Korean J Gastroenterol. 2004;44(3):113-125.