YAKHAK HOEJI (약학회지)

The Pharmaceutical Society of Korea (대한약학회)
권호 표지

Activation of Hypoxia Inducible Factor-1 Alpha by Estrogen Receptor Alpha

에스트로젠 수용체알파에 의한 Hypoxia Inducible Factor-1의 전사 활성조절

  • Ryu, Kwang-Hee (College of Life Science, Institute of Biotechnology, Department of Bioscience and Biotechnology, Sejong University) ;
  • Lee, Young-Joo (College of Life Science, Institute of Biotechnology, Department of Bioscience and Biotechnology, Sejong University)
  • 유광희 (세종대학교 생명공학과) ;
  • 이영주 (세종대학교 생명공학과)
  • Received : 2009.09.24
  • Accepted : 2009.12.03
  • Published : 2010.04.30
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Abstract

Our previous results showed that hypoxia inducible factor-1 (HIF-1) activated estrogen receptor (ER) in the absence of ligand. In this study, we have studied the effect ER overexpression on the activation of HIF-1. ER overexpression induced transcription activation of hypoxia response element driven luciferase and vascular endothelial growth factor. As a negative control, the effect of ER on androgen receptor response element was used. Our result indicate that the two ER$\alpha$ and HIF-1 signaling pathways shares part of the activation pathway.

Keywords

References

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