Journal of Physiology & Pathology in Korean Medicine (동의생리병리학회지)

The Physiological Society of Korean Medicine and The Society of Pathology in Korean Medicine (대한동의생리학회·한의병리학회)
권호 표지

Effects of Taeumjowe-tang-gagambang on the Glycometabolism and Lipidmetabolism in the Liver Tissue of Diet-induced Obesity Mice

비만 유도 흰쥐 간조직에서 태음조위탕(太陰調胃湯) 가감방(加減方)이 당과 지질대사에 미치는 영향

  • Hsiao, Mei Hui (Department of Oriental Internal Medicine, College of Oriental Medicine, Kyungwon University) ;
  • Ko, Seong-Gyu (Preventive Medicine, College of Oriental Medicine, Kyunghee University) ;
  • Jun, Chan-Yong (Department of Oriental Internal Medicine, College of Oriental Medicine, Kyungwon University) ;
  • Park, Jong-Hyeong (Department of Oriental Internal Medicine, College of Oriental Medicine, Kyungwon University) ;
  • Choi, You-Kyung (Department of Oriental Internal Medicine, College of Oriental Medicine, Kyungwon University)
  • 소미혜 (경원대학교 한의과대학 내과학교실) ;
  • 고성규 (경희대학교 한의과대학 예방의학과) ;
  • 전찬용 (경원대학교 한의과대학 내과학교실) ;
  • 박종형 (경원대학교 한의과대학 내과학교실) ;
  • 최유경 (경원대학교 한의과대학 내과학교실)
  • Received : 2010.06.01
  • Accepted : 2010.07.14
  • Published : 2010.08.25
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Abstract

The aim of this study was to investigate the effect of Taeeumjowuitanggagam-bang (TJV) on the mRNA expression of Sterol regulatory element binding proteins (SREBPs), Tumor necrosis factor-$\alpha$ (TNF-$\alpha$) and Interlukin-6 (IL-6) that are considered to play an important role in lipid and glucose metabolism. For diet-induced obese studies, we split mice into 2 groups. The low fat diet group (LFD, n=8) were supplied with general diet for 10 weeks and the high fat diet group (HFD, n=18) were supplied with 60 kcal% fat diet for 10 weeks. And then The HFD group, the diet-induced obese group, were divided into 3 groups ; a group supplied with normal saline, a group treated with TJV 200 mg/kg and a group treated with TJV 500 mg/kg. They were treated orally with TJV and measured their body weight every day during 10 weeks. After that, we measured mRNA expressions of TNF-$\alpha$, IL-6 and SREBP-1c in liver, and blood concentrations of glucose, total cholesterol and triglyceride too. The results are as follows. The TJV reduced glucose and total cholesterol of blood concentration. The TJV reduced the mRNA expressions of TNF-$\alpha$ and SREBPs in liver. However, We couldn't find the TJV effects on the mRNA expression of IL-6, triglyceride blood concentration, and body weight among groups. The TJV stained liver tissue less red than control group. These results suggest that TJV may be effective for regulation of lipid and glucose metabolism in liver.

Keywords

References

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