Nutrition Research and Practice

  • 제4권3호
  • /
  • Pages.203-207
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  • 2010
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  • 1976-1457(pISSN)
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  • 2005-6168(eISSN)
한국영양학회 (The Korean Nutrition Society)
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The effect of Oligonol intake on cortisol and related cytokines in healthy young men

  • Lee, Jeong-Beom (Department of Physiology, College of Medicine, Soonchunhyang University) ;
  • Shin, Young-Oh (Department of Physiology, College of Medicine, Soonchunhyang University) ;
  • Min, Young-Ki (Department of Physiology, College of Medicine, Soonchunhyang University) ;
  • Yang, Hun-Mo (Department of Physiology, College of Medicine, Soonchunhyang University)
  • 투고 : 2009.11.13
  • 심사 : 2010.05.24
  • 발행 : 2010.06.30
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초록

This study investigated the effects of Oligonol intake on cortisol, interleukin (IL)-$1{\beta}$, and IL-6 concentrations in the serum at rest and after physical exercise loading. Nineteen healthy sedentary male volunteers participated in this study. The physical characteristics of the subjects were: a mean height of $174.2{\pm}2.7$ cm, a mean weight of $74.8{\pm}3.6$ kg and a mean age of $22.8{\pm}1.3$ years. Each subject received 0.5 L water with Oligonol (100 mg/day) (n = 10) or a placebo (n = 9) daily for four weeks. The body composition, the white blood cell (WBC) and differential counts as well as the serum cortisol, IL-$1{\beta}$, and IL-6 concentrations were measured before and after Oligonol intake. The cortisol concentration and serum levels of IL-$1{\beta}$ and IL-6 after Oligonol intake were significantly decreased compared to before treatment (P < 0.01, respectively). In addition, the rate of increase of these factors after exercise was decreased compared to the placebo group. There was no change in the WBC and differential cell counts. These results suggest that oral Oligonol intake for four weeks had a significant effect on inhibition of inflammatory markers in healthy young men.

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참고문헌

  1. Aruoma OI. Methodological considerations for characterizing potential antioxidant actions of bioactive components in plant foods. Mutat Res 2003;523-524:9-20. https://doi.org/10.1016/S0027-5107(02)00317-2
  2. Owen RW, Giacosa A, Hull WE, Haubner R, Spiegelhalder B, Bartsch H. The antioxidant/anticancer potential of phenolic compounds isolated from olive oil. Eur J Cancer 2000;36: 1235-47. https://doi.org/10.1016/S0959-8049(00)00103-9
  3. Aruoma OI, Sun B, Fujii H, Neergheen VS, Bahorun T, Kang KS, Sung MK. Low molecular proanthocyanidin dietary biofactor oligonol: its modulation of oxidative stress, bioefficacy, neuroprotection, food application and chemoprevention potentials. Biofactors 2006;27:245-65. https://doi.org/10.1002/biof.5520270121
  4. Middleton E Jr, Kandaswami C, Theoharides TC. The effects of plant flavonoids on mammalian cells: implications for inflammation, heart disease and cancer. Pharmacol Rev 2000;52:673-751.
  5. Scalbert A, Johnson IT, Saltmarsh M. Polyphenols: antioxidants and beyond. Am J Clin Nutr 2005;81:215S-217S. https://doi.org/10.1093/ajcn/81.1.215S
  6. Soobrattee MA, Neergheen VS, Luximon-Ramma A, Aruoma OI, Bahorun T. Phenolic as potential antioxidant therapeutic agents: mechanism and actions. Mutat Res 2005;579:200-13. https://doi.org/10.1016/j.mrfmmm.2005.03.023
  7. Soobrattee MA, Bahorun T, Aruoma OI. Chemopreventive actions of polyphenolic compounds in cancer. Biofactors 2006; 27:19-35. https://doi.org/10.1002/biof.5520270103
  8. Nakagawa T, Yokozawa T, Satoh A, Kim HY. Attenuation of renal ischemia-reperfusion injury by proanthocyanidin-rich extract from grape seeds. J Nutr Sci Vitaminol (Tokyo) 2005;51:283-6. https://doi.org/10.3177/jnsv.51.283
  9. Li MH, Jang JH, Sun B, Surh YJ. Protective effects of oligomers of grape seed polyphenols against b-amyloid-induced oxidative cell death. Ann N Y Acad Sci 2004;1030:317-29. https://doi.org/10.1196/annals.1329.040
  10. Fujii H, Yokozawa T, Kim YA, Tohda C, Nonaka G. Protective effect of grape seed polyphenols against high glucose-induced oxidative stress. Biosci Biotechnol Biochem 2006;70:2104-11. https://doi.org/10.1271/bbb.60053
  11. Fujii H, Sun B, Nishioka H, Hirose A, Aruoma OI. Evaluation of the safety and toxicity of the oligomerized polyphenol Oligonol. Food Chem Toxicol 2007;45:378-87. https://doi.org/10.1016/j.fct.2006.08.026
  12. Drenth JP, Van Uum SH, Van Deuren M, Pesman GJ, Van der Ven-Jongekrijg J, Van der Meer JW. Endurance run increases circulating IL-6 and IL-1ra but down regulates ex vivo TNF-${\alpha}$ and IL-$1{\beta}$ production. J Appl Physiol 1995;79:1497-503. https://doi.org/10.1152/jappl.1995.79.5.1497
  13. Ostrowski K, Rohde T, Asp S, Schjerling P, Pedersen BK. Pro- and anti-inflammatory cytokine balance in strenuous exercise in humans. J Physiol 1999;515:287-91. https://doi.org/10.1111/j.1469-7793.1999.287ad.x
  14. Belcastro AN, Arthur GD, Albisser TA, Raj DA. Heart, liver, and skeletal muscle myeloperoxidase activity during exercise. J Appl Physiol 1996;80:1331-5. https://doi.org/10.1152/jappl.1996.80.4.1331
  15. Nishioka H, Fujii H, Sun B, Aruoma OI. Comparative efficacy of oligonol, catechin and (-)-epigallocatechin 3-O-gallate in modulating the potassium bromate-induced renal toxicity in rats. Toxicology 2006;226:181-7. https://doi.org/10.1016/j.tox.2006.06.017
  16. Tomobe K, Fujii H, Sun B, Nishioka H, Aruoma OI. Modulation of infection-induced inflammation and locomotive deficit and longevity in senescence-accelerated mice-prone (SAMP8) model by the oligomerized polyphenol oligonol. Biomed Pharmacother 2007; 61:427-34. https://doi.org/10.1016/j.biopha.2007.05.007
  17. Kundu JK, Chang EJ, Fujii H, Sun B, Surh YJ. Oligonol inhibits UVB-induced COX-2 expression in HR-1 hairless mouse skin: AP-1 and C/EBP as potential upstream targets. Photochem Photobiol 2008;84:399-406. https://doi.org/10.1111/j.1751-1097.2007.00277.x
  18. Sakurai T, Nishioka H, Fujii H, Nakano N, Kizaki T, Radak Z, Izawa T, Haga S, Ohno H. Antioxidative effects of a new lychee fruit-derived polyphenol mixture, oligonol, converted into a low-molecular form in adipocytes. Biosci Biotechnol Biochem 2008;72:463-76. https://doi.org/10.1271/bbb.70567
  19. Northoff H, Berg A, Weinstock C. Similarities and differences of the immune response to exercise and trauma: the IFN-concept. Can J Physiol Pharmacol 1998;76:497-504. https://doi.org/10.1139/y98-052
  20. Gleeson M. Immune function in sport and exercise. J Appl Physiol 2007;103:693-9. https://doi.org/10.1152/japplphysiol.00008.2007
  21. Metz JR, Huising MO, Leon K, Verburg-van Kemenade BM, Flik G. Central and peripheral interleukin-$1{\beta}$ and interleukin-1 receptor 1 expression and their role in the acute stress response of common carp, Cyprinus carpio L. J Endocrinol 2006;191:25-35. https://doi.org/10.1677/joe.1.06640
  22. O'Connor KA, Johnson JD, Hansen MK, Wieseler Frank JL, Maksimova E, Watkins LR, Maier SF. Peripheral and central proinflammatory cytokine response to a severe acute stressor. Brain Res 2003;991:123-32. https://doi.org/10.1016/j.brainres.2003.08.006
  23. Dinarello CA. Interleukin-1 and interleukin-1 antagonism. Blood 1991;77:1627-52.
  24. Benjamin D, Sharma V, Kubin M, Klein JL, Sartori A, Holliday J, Trinchieri G IL-12 expression in AIDS-related lymphoma B cell lines. J Immunol 1996;156:1626-37.
  25. Kang K, Kubin M, Cooper KD, Lessin SR, Trinchieri G, Rook AH. IL-12 synthesis by human langerhans cells. J Immunol 1996;156:1402-7.
  26. Kaplan A, Baeza M, Reddigari S, Kuna P. Histamine-releasing factors. Int Arch Allergy Appl Immunol 1991;94:148-53. https://doi.org/10.1159/000235348
  27. Cannon JG, Evans WJ, Hughes VA, Meredith CN, Dinarello CA. Physiological mechanisms contributing to increased interleukin-1 secretion. J Appl Physiol 1986;61:1869-74. https://doi.org/10.1152/jappl.1986.61.5.1869
  28. Shephard RJ, Rhind S, Shek PN. Exercise and the immune system: natural killer cells, interleukins and related responses. Sports Med 1994;18:340-69. https://doi.org/10.2165/00007256-199418050-00006
  29. Tilg H, Dinarello CA, Mier JW. IL-6 and APPs: anti-inflammatory and immunosuppressive mediators. Immunol Today 1997;18: 428-32. https://doi.org/10.1016/S0167-5699(97)01103-1

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