Animal cells and systems

The Korean Society for Integrative Biology (한국통합생물학회)
권호 표지
DOI QR코드

DOI QR Code

Assessment of long-term working memory by a delayed nonmatch-to-place task using a T-maze

  • Kim, Jung-Eun (National Creative Research Initiative Center for Memory, Department of Biological Sciences, College of Natural Sciences, Seoul National University) ;
  • Choi, Jun-Hyeok (National Creative Research Initiative Center for Memory, Department of Biological Sciences, College of Natural Sciences, Seoul National University) ;
  • Kaang, Bong-Kiun (National Creative Research Initiative Center for Memory, Department of Biological Sciences, College of Natural Sciences, Seoul National University)
  • Received : 2009.10.05
  • Published : 2010.03.31
Download PDF
⟨ Previous Next ⟩

Abstract

Long-term working memory (LTWM) is a subdivision concept of working memory and indicates the enhancement of performance in a working memory task. LTWM has been shown in humans who have been engaged in a specific task requiring working memory over a long time. However, there is very little understanding of the exact mechanism of LTWM because of limitations of experimental methods in human studies. We have modified the standard T-maze task, which is used to test working memory in mice, to demonstrate LTWM in an animal model. We observed an enhancement of performance by repeated experience with the same working memory load in mice, which can be regarded as an LTWM. This effect seems to depend on the condition wherein a delay was given. This task may be a good experimental protocol to assess LTWM in animal studies.

Keywords

References

  1. Atkinson RC, Shiffrin RM. 1968. The psychology of learning and motivation: advances in research and theory. New York: Academic Press.
  2. Baddeley A. 1992. Working memory. Science. 255:556-559. https://doi.org/10.1126/science.1736359
  3. Bolhuis JJ, Buresova O, Bures J. 1985. Persistence of working memory of rats in an aversively motivated radial maze task. Behav Brain Res. 15:43-49. https://doi.org/10.1016/0166-4328(85)90016-6
  4. Deacon RM, Rawlins JN. 2006. T-maze alternation in the rodent. Nat Protoc. 1:7-12. https://doi.org/10.1038/nprot.2006.2
  5. Deacon RMJ, Penny C, Rawlins JNP. 2003. Effects of medial prefrontal cortex cytotoxic lesions in mice. Behav Brain Res. 139:139-155. https://doi.org/10.1016/S0166-4328(02)00225-5
  6. Dember WN, Fowler H. 1958. Spontaneous alternation behavior. Psychol Bull. 55:412-428. https://doi.org/10.1037/h0045446
  7. Ericsson KA, Kintsch W. 1995. Long-term working memory. Psychol Rev. 102:211-245. https://doi.org/10.1037/0033-295X.102.2.211
  8. Kellogg RT. 2001. Long-term working memory in text production. Mem Cognit. 29:43-52. https://doi.org/10.3758/BF03195739
  9. Lalonde R. 2002. The neurobiological basis of spontaneous alternation. Neurosci Biobehav Rev. 26:91-104. https://doi.org/10.1016/S0149-7634(01)00041-0
  10. Masuda Y, Murai S, Saito H, Abe E, Kohori I, Itoh T. 1992. [A simple method using a maze task for estimating working memory in mice]. Yakubutsu Seishin Kodo. 12:27-32.
  11. Postal V. 2004. Expertise in cognitive psychology: testing the hypothesis of long-term working memory in a study of soccer players. Percept Mot Skills. 99:403-420. https://doi.org/10.2466/pms.99.2.403-420
  12. Sohn YW, Doane SM. 2003. Roles of working memory capacity and long-term working memory skill in complex task performance. Mem Cognit. 31:459-466.
  13. Takao K, Toyama K, Nakanishi K, Hattori S, Takamura H, Takeda M, Miyakawa T, Hashimoto R. 2008. Impaired long-term memory retention and working memory in sdy mutant mice with a deletion in Dtnbp1, a susceptibility gene for schizophrenia. Mol Brain. 1:11. https://doi.org/10.1186/1756-6606-1-11
  14. Weitzdoerfer R, Hoeger H, Engidawork E, Engelmann M, Singewald N, Lubec G, Lubec B. 2004. Neuronal nitric oxide synthase knock-out mice show impaired cognitive performance. Nitric Oxide. 10:130-140. https://doi.org/10.1016/j.niox.2004.03.007
  15. Wenk GL. 2001. Assessment of spatial memory using the T maze. Curr Protoc Neurosci. Chapter 8:Unit 8 5B.

Cited by

  1. Strategic neuronal encoding in medial prefrontal cortex of spatial working memory in the T-maze vol.343, pp.None, 2018, https://doi.org/10.1016/j.bbr.2018.01.020