Journal of Oriental Neuropsychiatry (동의신경정신과학회지)

The Korean Society of Oriental Neuropsychiatry (대한한방신경정신과학회)
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Effects of Korean Mountain Ginseng Leaves and Its Active Constituents on Scopolamine-induced Amnesia in Mouse

장뇌삼 잎 추출물의 분획물이 Scopolamine으로 유도된 Mouse의 기억력 개선에 미치는 영향

  • Kim, Ju-Bong (Dept. of Oriental Neuropsychiatry, College of Oriental Medicine, Dae-Gu Hanny University) ;
  • Kim, Soo-Hyun (Dept. of Oriental Neuropsychiatry, College of Oriental Medicine, Dae-Gu Hanny University) ;
  • Park, Sun-Young (Dept. of Oriental Neuropsychiatry, College of Oriental Medicine, Dae-Gu Hanny University) ;
  • Chung, Dae-Kyoo (Dept. of Oriental Neuropsychiatry, College of Oriental Medicine, Dae-Gu Hanny University)
  • 김주봉 (대구한의대학교 한의과대학 신경정신과 교실) ;
  • 김수현 (대구한의대학교 한의과대학 신경정신과 교실) ;
  • 박선영 (대구한의대학교 한의과대학 신경정신과 교실) ;
  • 정대규 (대구한의대학교 한의과대학 신경정신과 교실)
  • Received : 2010.01.20
  • Accepted : 2010.03.08
  • Published : 2010.03.30
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Abstract

Objectives: The purpose of this study was to characterize the effect of the fraction of Korean mountain ginseng folium (FKG) on the learning and memory impairments induced by scopolamine. Methods: The memory ameliorating effect of FKG was investigated using a passive avoidance test, the Y-maze test, and the Morris water maze test in mice. Drug-induced amnesia was induced by treating animals with scopolamine(1mg/kg, i.p.). Results: FKG (2 or 4mg/kg, p.o.) administration significantly reversed scopolamine-induced cognitive impairments in mice by the passive avoidance test and the Y-maze test(P<0.05), and also improved escape latency in the Morris water maze test at 2 or 4mg/kg(P<0.05). Although FKG has little inhibitory activity for AChE (IC50 value; 1847 ${\mu}g/ml$) in an invitro study, phosphorylated extracellular signal-regulated kinase(pERK) was increased by the administration of FKG inhippocampus on immunohistochemistry. Conclusions: These results suggest that FKG may be a useful cognitive impairment treatment, and its beneficial effects are mediated, in part, via activation of ERK pathway.

Keywords

References

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