참고문헌
- Sinha S, Anderson JP, Barbour R, Basi GS, Caccavello R, Davis D, et al. Purification and cloning of amyloid precursor protein beta-secretase from hunan brain. Nature. 1999; 402:537-40. https://doi.org/10.1038/990114
- Selkoc DJ. Alzheimer's disease: a central role for amyloid. J. Neuropathol. Exp. Neurol. 1994; 53:438-47.
- Vassar R, Bennett BD, Babu-Khan S, Kahn S, Mendiaz EA, Denis P, et aI. Beta-secretase cleavage of Alzheimer's amyloid precursor protein by the transmembrane aspartic protease BACE. Science. 1999;286:735-41. https://doi.org/10.1126/science.286.5440.735
- Roberds SL, Anderson J, Basi G, Michael J, Bienkowski MJ, Branstetter DG, et al. BACE knockout mice are healthy despite lacking the primary beta-secretase activity in brain : implications for Alzheimer' s disease therapeutics, Hum. mol. genet. 2001;10:1317-24. https://doi.org/10.1093/hmg/10.12.1317
- 許浚. 東醫寶鑑. 서울:大星文化社. 1996:55-6.
- 李尙仁 외. 漢藥臨床應用. 서울:成輔社. 1990: 151-3, 308-13, 419-20, 426-8.
- 김영욱, 송태원, 오민석. 총명탕이 건망유도백서의 학습과 기억에 미치는 영향. 한방재활의학과학회지. 1998;8(2):464-79.
- 하수영, 정인결, 이상룡. 총명탕과 산사총명탕이 Alzheimer' s Disease 병태 모델에 미치는 영향. 동의신경정신과학회지. 2006;17(1):59-78.
- 임정화, 정인철, 이상룡. 총명탕과 파극천총명탕 열수추출물, 초미세분말제형이 microglia 및 기억력 감퇴 병태모델에 미치는 영향, 동의생리병리학회지. 2006;20(4):997-1008.
- 암정화, 이상룡. 팔미합총명탕 열수추출불, 초미세분말제형이 Alzheimer' s Disease 병태 모델에 마치는 영향, 동의신경정신과학회지. 2008;19(2):95-110.
- 김현주, 이상룡. 가미보양환오탕과 팔미합총명 탕의 microglia 보호, 항산화 및 acetylcholinesterase 억제 효과. 동의신경정신과학회지. 2008;19(2):65-75.
- 이승희, 정인철, 이상룡. 歸脾聰明湯 열수추출불과 초미세분말제형이 Alzheimer' s Disease 병태 모델에 미치는 영향. 동의생리병리학회지. 2007;21 (4) :921-33.
- 정인철, 이상룡. 聰明湯과 木槿皮聰明湯 열수추출물, 초미세분말제형이 microglia 및 기억력 감퇴 병태모델에 미치는 영향. 동의생리병리학회지. 2006;20(2):1200-10.
- 서승호, 정인철, 이상룡. 聰明湯和山査聰明湯 熱水提取物, 超微細粉末劑形的小膠質細胞及記憶力減退 病態模型的影響. 제5회 국제중의약 학술연토회의논문집. 2006;325-7.
- 김현수, 정인철, 이상룡. 파극천이 치매병태모델에 미치는 영향. 동의신경정신과학회지 .2003; 14(1 ):45-58.
- 채종걸, 정인철, 이상룡. 산사육이 CT105로 유도된 Alzhcimer' S Disease 병태 모텔에 미치는 영향. 동의신경정신과학회지. 2002;13(1):79-115.
- Blasi E, Barluzzi R, Bocchini V, Mazzolla R, Bistoni F. Immortalization of murine microglial cells by a v-raf/v-myc carrying retrovirus. J. Neurohmnunol. 1990;27(2-3):229-37.
- Witney AA, Doolan DL, Anthony RM, Weiss WR, Hoffman SL, Carucci DJ. Determining liver stage parasite burden by real time quantitative PCR as a method for evaluating pre-crythrocytic malaria vaccine efficacy. Mol. Biochem. Parasitol. 2001;118(2):233-45. https://doi.org/10.1016/S0166-6851(01)00372-3
- Yunzhou Dong. Jianxin Tan, Mei-Zhen Cui, Guojun Zhao, Guozhang Mao, Neena Singh and Xuemin Xu. Calpain inhibitor MDl28170 modulates AB formation by inhibiting the formation of intermediate AB46 and protecting AB from degradation. The FASEB Journal. 2006;20:331-3.
- Chen G, Chen KS, Knox J. Inglis J, Bernard A, Martin SJ, et aI. A learning deficit related to age and beta-amyloid plaques in a mouse model of Alzheimer' disease. Nature. 2000;408:975-9. https://doi.org/10.1038/35050103
- Citron M, Diehl TS, Gordon G, Biere AL, Scubert P, Selkoc DJ. Evidence that the 42- and 40-amino acid forms of amyloid beta protein are generated from the beta-amyloid precursor protein by different protease activities. Proc. Natl. Acad. Sci. USA. 1996; 93:13170-5. https://doi.org/10.1073/pnas.93.23.13170
- John V, Beck Jp, Bienkowski MJ, Sinha S, Heinrikson RL. Human beta-secretase (BACE) and BACE inhibitors. J. Med. Chem. 2003; 46(22):4625-30. https://doi.org/10.1021/jm030247h
- Je JY, Kim SK. Water-soluble chitosan derivatives as a BACE1 inhibitor. Bioorg. Med. Chem. Lett. 2005;13:6551-5. https://doi.org/10.1016/j.bmc.2005.07.004
- Stachel SJ, Coburn CA, Steele TG, Jones KG, Loutzenhiser EF, Gregro AR, Rajapakse HA, Lai MT, Crouthamel MC, Xu M, Tugusheva K, Lineberger JE, Pietrak BL, Espeseth AS, Shi XP, Chen-Dodson E, Hollovvay MK, Munshi S, Simon AJ, Kuo L, Vacca, JP. Structure-based design of potent and selective cell-permeable inhibitors of human beta-secretase(BACE-1). J. Med. Chem. 2004;47(26):6447-50. https://doi.org/10.1021/jm049379g
- Wolfe MS. Therapeutic strategies for Alzheimer's disease. Nature Reviews Drug Discovery. 2002; 1:859-66. https://doi.org/10.1038/nrd938
- christensen MA, Zhou W, Qing H, Lehman A, Philipesn S, Song W. Transcriptional regulation of BACE1, the beta-amyloid precursor protein beta-secretase, by Sp1. Mol Cell Biol. 2004;24:865-74. https://doi.org/10.1128/MCB.24.2.865-874.2004