Journal of Life Science (생명과학회지)

Korean Society of Life Science (한국생명과학회)
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Sudden Death Caused by Clostridium perfringens Type D Enterotoxemia in Feedlot Cattle

비육 우의 Clostridium perfringens D 형 장독 혈증에 의한 폐사

  • Jang, Seong-Jun (College of Veterinary Medicine, Kyungpook National University) ;
  • Do, Sun-Hee (College of Veterinary Medicine, Konkuk University) ;
  • Ki, Mi-Ran (College of Veterinary Medicine, Kyungpook National University) ;
  • Hong, Il-Hwa (College of Veterinary Medicine, Kyungpook National University) ;
  • Park, Jin-Kyu (College of Veterinary Medicine, Kyungpook National University) ;
  • Cho, Yu-Jeong (College of Veterinary Medicine, Kyungpook National University) ;
  • Ji, Ae-Ri (College of Veterinary Medicine, Kyungpook National University) ;
  • Park, Se-Il (College of Veterinary Medicine, Kyungpook National University) ;
  • Park, Sang-Joon (College of Veterinary Medicine, Kyungpook National University) ;
  • Kim, Tae-Hwan (College of Veterinary Medicine, Kyungpook National University) ;
  • Kwak, Dong-Mi (College of Veterinary Medicine, Kyungpook National University) ;
  • Jeong, Kyu-Shik (College of Veterinary Medicine, Kyungpook National University)
  • Received : 2009.09.11
  • Accepted : 2010.05.14
  • Published : 2010.05.31
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Abstract

Sudden deaths have occurred in feedlot cattle with marked necro-hemorrhagic enteritis of the jejunum, ileum and colon. Suckling beef calves are the most frequently affected. Over-consumption of large amounts of milk, inadequate colostrum intake, chilling and stress are conducive to the development of enterotoxemia. Enterotoxemia caused by Clostridium perfringens type D mostly occurs following a sudden change of diet, particularly to feeds made richer in order to grow the cattle to market weight in feedlots. During July 2006, sudden deaths of cattle occurred in the Youngcheon regional area of Gyeongbuk province. There were no significant clinical signs except anorexia, depression, intermittent diarrhea and mild respiratory failure. Histological findings revealed a prominent intranuclear inclusion as well as infiltration of the globular leukocytes in various organs including the heart, kidneys, liver, spleen and lymph nodes. Spleen and lymphatic tissues showed lymphatic necrosis and a starry sky appearance. In the submucosa of the small intestines, basophilic aggregation was detected with massive infiltration of the globular leukocytes and eosinophils. Gram staining for the tissue sections containing inclusions of the small intestines revealed a positive histochemical reaction. Taken together, we suggest that Clostridium perfringens type D-induced enterotoxemia is determined to be the cause of sudden death of feedlot cattle.

비육우의 공장, 회장 및 결장의 특징적 괴사 출혈성 장염 증상은 폐사 증후군과 관련이 있는 것으로 인식되고 있다. 특히 젖먹이 송아지들이 폐사 증후군에 가장 영향을 받는데, 포유시 송아지에게 과식을 시키거나, 비위생적 초유 급유, 체온 하강 및 스트레스는 장독혈증 발생의 원인들이다. 2006년 7월 중 경북 영천 지역에서 축우의 폐사가 발생하였다. 식욕부진, 의기소침, 간헐적인 설사 및 경미한 호흡 곤란을 제외하고는 특별한 임상 증상은 없었으나, 조직학적 소견에 의하면, 심장, 신장, 간, 비장 및 임파선을 포함한 각종 기관에서 globular leukocytes 의 침윤뿐 아니라 핵내 봉입체가 현저하게 나타났다. 비장과 림프조직에서는 림프 괴사와 림프구 괴사로 인한 'starry sky appearance'를 나타내었다. 소장 점막 하에서는 다량의 globular leukocytes와 호산 구의 침윤과 함께 호 염기성 세포 집단이 관찰되었다. 봉입체가 있는 소장 조직의 단면은 그램 염색에 대해 조직 화학적으로 양성 반응을 나타내었다. 결론적으로, 비축우의 폐사 원인은 조직학적 및 조직화학적 분석 결과를 근거로 Clostridium perfringens D 형균에 의한 장독혈증으로 진단되었다.

Keywords

References

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