Journal of the Korean Society for Precision Engineering (한국정밀공학회지)

Korean Society for Precision Engineering (한국정밀공학회)
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Longitudinal Alterations on Lumbar Vertebral Trabecular Bone Qualities during Pregnancy

임신기간 중 척추 해면골의 골질(bone qualities) 변화

  • Ko, Chang-Yong (Department of Biomedical Engineering, College of Health Sciences, Yonsei University) ;
  • NamGung, Bum-Seok (Division of Bioengineering, National University of Singapore) ;
  • Kim, Hyo-Seon (Department of Biomedical Engineering, College of Health Sciences, Yonsei University) ;
  • Kim, Hyun-Dong (Department of Biomedical Engineering, College of Health Sciences, Yonsei University) ;
  • Kim, Han-Sung (Department of Biomedical Engineering, College of Health Sciences, Yonsei University)
  • 고창용 (연세대학교 보건과학대학 의공학과) ;
  • 남궁범석 (싱가폴 국립대학교 의공학과) ;
  • 김효선 (연세대학교 보건과학대학 의공학과) ;
  • 김현동 (연세대학교 보건과학대학 의공학과) ;
  • 김한성 (연세대학교 보건과학대학 의공학과)
  • Received : 2009.08.25
  • Accepted : 2010.02.11
  • Published : 2010.04.01
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Abstract

The aim of this study was to detect longitudinal alterations on lumbar vertebral trabecular bone quality (microarchitecture and degree of mineralization) and bone mineral density (BMD) during pregnancy Virginal eighteen mice were used. Then, twelve mice were mated. Mice lumbar vertebrae were scanned before mate, at 7 days of pregnancy (early pregnancy, 6 mice) and immediately after delivery (late pregnancy, 6 mice) by using in-vivo micro-computed tomography Structural parameters, degree of mineralization and BMD were measured. During early pregnancy, there were no significant alterations on structural parameters, degree of mineralization and BMD. At late pregnancy, Tb.Th (11.8%) and BMD (12.7%) were significantly decreased and Tb.N (6.3%), Tb.Pf (43.0%) and BS/BV (15.1%) were significantly increased (p<0.05). Additionally, the lower degree of mineralization was increased, although, the higher degree of mineralization was decreased. These results indicated that the quality and BMD might be not affected during early pregnancy. At late pregnancy, however the bone quality and BMD were likely to be negatively affected.

Keywords

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