Korean Journal of Pharmacognosy (생약학회지)

The Korean Society of Pharmacognosy (한국생약학회)
권호 표지

Activation of Innate Immunity by Lepiota procera Enhances Antitumor Activity

큰갓버섯(Lepiota procera) 추출물의 면역자극 활성에 의한 항암 증진 효과

  • Kim, Doh-Hee (Division of Clinical Research, Medical Institute, Seoul Medical Center) ;
  • Han, Kyung-Hoon (Division of Clinical Research, Medical Institute, Seoul Medical Center) ;
  • Song, Kwan-Yong (Division of Clinical Research, Medical Institute, Seoul Medical Center) ;
  • Lee, Kye-Heui (Division of Clinical Research, Medical Institute, Seoul Medical Center) ;
  • Jo, Sun-Young (Department of Food & Nutrition, Yuhan University) ;
  • Lee, Seog-Won (Department of Food & Nutrition, Yuhan University) ;
  • Yoon, Taek-Joon (Department of Food & Nutrition, Yuhan University)
  • Received : 2010.04.27
  • Accepted : 2010.06.09
  • Published : 2010.06.30
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Abstract

The present study was designed to explore an immunostimulating activity of crude extracts of Macrolepiota procera, and a combination therapy of cisplatin and Macrolepiota procera extracts which can potentiate the anti-cancer activity of cisplatin. For these, water extraction of Macrolepiota procera were performed at $4^{\circ}C$(MPE-4) and $100^{\circ}C$(MPE-100). In experimental metastasis of colon26-M3.1 cells, prophylactic intravenous administration of MPE ($80-2,000{\mu}g$/mouse) inhibited tumor metastasis compared with tumor control. Peritoneal macrophages stimulated with MPE produced IL-12 as well as induced tumoricidal activity. In an analysis of NK-cell activity, i.v. administration of MPE ($200{\mu}g$/mouse) significantly augmented NK cytotoxicity to YAC-1 tumor cells. The combination treatments of cisplatin ($20{\mu}g$) and MPE ($100{\mu}g$) exhibited prolongation of lifespan in colon26-M3.1 tumor bearing mouse. These results suggested that MPE stimulate immune system non-specifically and application as adjuvant in cancer treatment.

Keywords

References

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