Bulletin of the Korean Chemical Society

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Microwave Assisted One-pot Synthesis of Novel α-Aminophosphonates and heir Biological Activity

  • Received : 2010.02.03
  • Accepted : 2010.03.12
  • Published : 2010.07.20
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Abstract

A simple and efficient synthesis of various $\alpha$-aminophosphonates (3a-l) by the reaction of substituted aromatic/heterocyclic aldehydes, 2-amino-6-methoxy-benzothiazole and dibutyl/diphenyl phosphites under microwave irradiation without catalyst was accomplished. The phosphonates were characterized by elemental analysis, IR, $^1H$, $^{13}C$- and $^{31}PNMR$ spectra. They showed promising antimicrobial, anti-oxidant activities depending on the nature of bioactive groups at the $\alpha$-carbon.

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References

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