Journal of Sasang Constitutional Medicine (사상체질의학회지)

The Society Of Sasang Constitutional Medicine (사상체질의학회)
권호 표지

Safety on Hazardous Substances of Soeumin Kwakhyangjeonggi-san

소음인(少陰人) 곽향정기산(藿香正氣散)의 위해물질에 대한 안전성 연구

  • Seo, Chang-Seob (Herbal Medicine EBM Research Center, Korea Institute of Oriental Medicine) ;
  • Kim, Jung-Hoon (Herbal Medicine EBM Research Center, Korea Institute of Oriental Medicine) ;
  • Huang, Dae-Sun (Herbal Medicine EBM Research Center, Korea Institute of Oriental Medicine) ;
  • Shin, Hyeun-Kyoo (Herbal Medicine EBM Research Center, Korea Institute of Oriental Medicine)
  • 서창섭 (한국한의학연구원 한약EBM연구센터) ;
  • 김정훈 (한국한의학연구원 한약EBM연구센터) ;
  • 황대선 (한국한의학연구원 한약EBM연구센터) ;
  • 신현규 (한국한의학연구원 한약EBM연구센터)
  • Received : 2010.04.30
  • Accepted : 2010.05.27
  • Published : 2010.09.30
Download PDF
⟨ Previous Next ⟩

Abstract

1. Objective: To compare the contents and transfer rate of hazardous substances in crude, washing solution, crude after washing, decoction and remnant after boiling. 2. Methods: The heavy metal contents of each step were measured by inductively coupled plasma mass spectrometer (ICP-MS) and mercury analyzer (MA-2). In order to analyze pesticides in each sample we used simultaneous multi-residue analysis of pesticides by GC/ECD, which was followed by GC/MSD analysis to confirm the identity of the detected pesticide in each sample. In addition, the contents of sulfur dioxide (SO2) were performed by Monier-Williams distillation method. 3. Results: 1) Contents (mg/kg) of heavy metals in decoction of all herbal medicine prescriptions were not detected. 2) Transfer rates (%) of heavy metals from crude to remnant were As (83.3%), Cd (100.0%), Pb (182.6%) and Hg (100.0%). 3) Contents (mg/kg) of residual pesticides were not detected. 4) Transfer rate (%) of sulfur dioxide (SO2) from crude to remnant was 44.2%. 4. Conclusion: Our results showed that boiled herbal medicine prescriptions which we take is safe from the hazardous substances.

Keywords

References

  1. Lee JM. Dongeuisusebowon. Seoul:Daeseong Munhwasa. 1998:37. (Korean)
  2. Ahn BK, Song JM. Anti-allergy action of Soeumin Kwakhyangjeonggisan. J Sasang Constitut Med. 2001; 13:75-88. (Korean)
  3. Koh BH, Koo DM, Kim KY, Kim DR, Kim IH, Kim JY, et al. SasangMedicine. Seoul:Jipmoondang. 2004: 651-2, 678. (Korean)
  4. Won JS. Donguisasangsinpyeon. Daegu:Hanlimwon. 1990:24-6, 42. (Korean)
  5. Park HM, Choi KH, Jung JY, Lee SD. Metal exposure through consumption of herbal medicine, and estimation of health risk among korean population. Kor J Env Hlth. 2006;32:186-191. (Korean)
  6. Park CH, Kim KH. A study on heavy metals and residual percepticides in several herb medicines. J Korean Oriental Med Pathology. 1988;3(1):99-106. (Korean)
  7. Kim KJ, Yang CH, Kwon YK, Lee HJ. Studies on the heavy metal contents in cultivated herbal medicines and their soils at north kyungbuk area. Korean J Oriental Physiology & Pathology. 2003;17(6):1419-26. (Korean)
  8. Kim JW, Choi HY, Cho JH, Kim DH, Kang IH, Shim YH et al. Studies on monitoring hazardous substances of natural medicines (I) - Studies on heavy metals of natural medicines in market. Kor J Herbology. 2002;17(2):235-45. (Korean)
  9. Heo SK, Cha YY, Kim EG, Cho WH, Lee H, Baik TH et al. Determination of heavy metals, sulfur dioxide and residual pepsticides in oriental medical materials at Sangji university oriental medical hospital. Korean J Oriental Physiology & Pathology. 2008;22(4):948-53. (Korean)
  10. Cha YY, Heo SK, Kim DG, Baik TH, Seo HS, Park HS et al. Determination of heavy metals and residual pepsticides in oriental medical materials - Cultivated oriental medical materals at Sangji university oriental medical hospital. Korean J Oriental Physiology & Pathology. 2007;21(1):226-30. (Korean)
  11. Kim JS, Hwang SW, Kim JM, Ma JY. Monitoring research for heavy metals as endocrine disruptors in herbal medicines and ssangwha-tang. Korean J Oriental Med. 2000;6(1):117-22. (Korean)
  12. Seo CS, Huang DS, Lee JK, Ha HK, Chun JM, Um YR, Jang S, Shin HK. Concentration of heavy metals, residual pesticides and sulfur dioxide of before/after a decoction. - In prescription of cold. Kor J Herbology. 2008;23(4):51-8. (Korean)
  13. Seo CS, Huang DS, Lee JK, Ha HK, Chun JM, Um YR, Jang S, Shin HK. Concentration of heavy metals, residual pesticides and sulfur dioxide of before/after a decoction. - In prescription of digestive system. Kor J Herbology. 2009;24(1):111-9. (Korean)
  14. Seo CS, Huang DS, Lee JK, Ha HK, Chun JM, Um YR, et al. Concentration of heavy metals, residual pesticides and sulfur dioxide before/after a decoction. - In prescription consist of Sipjeondaebo-tang. J Korean Oriental Med. 2009;30(4):108-17. (Korean)
  15. Seo CS, Huang DS, Lee JK, Ha HK, Chun JM, Um YR, et al. Concentration of hazardous substances of before/after a decoction. - In prescription of high frequency. Kor J Herbology. 2009;24(2):13-20. (Korean)
  16. Seo CS, Huang DS, Lee JK, Ha HK, Chun JM, Um YR, et al. Concentration of hazardous substances of before/after a decoction in prescription of herbal medicine - In prescription of tonify Yang and tonify Yin. Kor J Orient Med Prescription. 2009;17(2):53-63. (Korean)
  17. Seo CS, Huang DS, Lee JK, Ha HK, Chun JM, Um YR, et al. Concentration of heavy metals, residual pesticides and sulfur dioxide of before/after a decoction. J Sasang Constitut Med. 2009;21:237-246. (Korean)
  18. Lee SD, Park HM, Lee JC, Kook YB. Concentration of metal in herbal drugs - in crude, remnant after boiling and decoction of herbal drugs. J Korean Oriental Med. 2003;24(2):59-65. (Korean)
  19. Park MK. Concentration of heavy metal in sagunjatang, decoction and its ingredient herbal medicines. J Environ Sci. 2007;16(2):241-5. https://doi.org/10.5322/JES.2007.16.2.241
  20. Cho SW. Park SS. A case of Gwaghyangjungkisan on Soeumin with papular eruption resulted from gingko- leaves medicine. J Sasang Constitut Med. 2003;15: 111-116. (Korean)
  21. Suh JY, S대 EH, Park SJ, Goo DM. The antimicrobial activity of Bojungikgi-tang, Gwakhyangjeonggi-san, and Gunggwihyangso-san to Klebsiella pneumoniae 289 extracted from allergic rhinitis patients. J Sasang Constitut Med. 2004;16(3):85-95. (Korean)
  22. Yun HS, Ryu BH, Park DW, Ryu KW. Experimental comparative studies on the effects of Kwakhyangjeonggisan and Souminkwakhyangjeonggisan. Kyunghee Univ. 1998;21(1):197-211. (Korean)