Analytical Science and Technology (분석과학)

The Korean Society of Analytical Sciences (한국분석과학회)
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Characteristics of tamiflu occurrence in surface water using LC/MS/MS

LC/MS/MS를 이용한 하천수 중 항바이러스제 타미플루 잔류 특성

  • Shin, Sun-Kyoung (National Institute of Environmental Research of Environmental Research, Chemical Behavior Research Division) ;
  • Kang, Young-Yeul (National Institute of Environmental Research of Environmental Research, Chemical Behavior Research Division) ;
  • Park, Jin-Soo (National Institute of Environmental Research of Environmental Research, Chemical Behavior Research Division) ;
  • Koo, So-Hyun (National Institute of Environmental Research of Environmental Research, Chemical Behavior Research Division) ;
  • Hwang, Seung-Ryul (National Institute of Environmental Research of Environmental Research, Chemical Behavior Research Division) ;
  • Kim, Woo-Il (National Institute of Environmental Research of Environmental Research, Chemical Behavior Research Division) ;
  • Song, Ki-Bong (National Institute of Environmental Research of Environmental Research, Chemical Behavior Research Division) ;
  • Kim, Young-Hee (National Institute of Environmental Research of Environmental Research, Chemical Behavior Research Division) ;
  • Kim, Tae-Seung (National Institute of Environmental Research of Environmental Research, Drinking Water Research Division) ;
  • Han, Jin-Suk (National Institute of Environmental Research of Environmental Research, Chemical Behavior Research Division)
  • 신선경 (국립환경과학원 환경건강위해성연구부 화학물질거동연구과) ;
  • 강영렬 (국립환경과학원 환경건강위해성연구부 화학물질거동연구과) ;
  • 박진수 (국립환경과학원 환경건강위해성연구부 화학물질거동연구과) ;
  • 구소현 (국립환경과학원 환경건강위해성연구부 화학물질거동연구과) ;
  • 황승률 (국립환경과학원 환경건강위해성연구부 화학물질거동연구과) ;
  • 김우일 (국립환경과학원 환경건강위해성연구부 화학물질거동연구과) ;
  • 송기봉 (국립환경과학원 환경건강위해성연구부 화학물질거동연구과) ;
  • 김영희 (국립환경과학원 환경건강위해성연구부 화학물질거동연구과) ;
  • 김태승 (국립환경과학원 물환경연구부 먹는물연구과) ;
  • 한진석 (국립환경과학원 환경건강위해성연구부 화학물질거동연구과)
  • Received : 2010.02.19
  • Accepted : 2010.03.31
  • Published : 2010.04.25
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Abstract

Oseltamivir carboxylate (OC) and Oseltamivir ethylester (OE) were analyzed to evaluate the environmental distribution in pandemic season in Korea. The detected concentration of OE was the range of $0.008\sim0.087\;{\mu}g/L$, and OC was the range of $0.029\sim0.287\;{\mu}g/L$. The detected concentration of OC in this study was two times higher than reported concentration of OC in river water in Japan. But, these analytical results cannot be directly compared to the previous reported concentration, because of the different sampling period.

본 연구에서는 최근 신종플루가 유행하여 수용성이 큰 항바이러스제인 타미플루(Oseltamivir ethylester phosphate, OEP)가 다량 사용됨에 따라 환경 중 잔류농도를 파악하고, 수생태 영향을 평가하고자 하천수를 채취하여 분석하였다. 타미플루의 주성분인 오설태미비르 에틸에스터(Oseltamivir ethylester, OE) 및 활성대사체 오설태미비르산(Oseltamivir carboxylate, OA)이 모든 지점에서 각각 $0.008\sim0.087\;{\mu}g/L$, $0.029\sim0.287\;{\mu}g/L$의 범위로 검출되었으며, OE보다 활성대사체(OA)가 상대적으로 높게 검출되었다. 이는 신종플루 대유행 이전인 일본 수질조사 결과에 비해 OA는 2배 높게 나타났으나, 시료채취 시기가 달라 직접적인 비교는 어려운 것으로 판단되었다.

Keywords

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