The Journal of Korean Medicine (대한한의학회지)

The Society of Korean Medicine (대한한의학회)
권호 표지

The Anti-obesity Effects of Gambi-bang 4(減肥 4號方) on Obesity-induced Mice

감비(減肥) 4호방(號方)이 비만이 유도된 생쥐에 미치는 영향

  • Hwang, Jae-Pil (Dept. of Orental Rehabilitation Medicine, College of Oriental Medicine, Dae-Jeon University) ;
  • Yoon, Il-Ji (Dept. of Orental Rehabilitation Medicine, College of Oriental Medicine, Dae-Jeon University)
  • 황재필 (대전대학교 한의과대학 한방재활의학과 교실) ;
  • 윤일지 (대전대학교 한의과대학 한방재활의학과 교실)
  • Received : 2009.07.13
  • Accepted : 2009.10.12
  • Published : 2010.01.30
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Abstract

Objectives: This study was performed to investigate the anti-obesity effects of Gambi-bang 4 (GBB4) on obesity-induced mice. Methods: C57BL/6 mice were divided into four groups (normal, high fat diet with control, high fat diet with Reductil, high fat diet with GBB4 extract) and fed for 8 weeks. We observed body weight change, the weight change of the adipocytes in body, total cholesterol, LDL-cholesterol, HDL-cholesterol and triglycerides, serum leptin level, expression of ${\beta}3AR$ and leptin genes in 3T3-L1 adipocytes and adipose tissue, and histological changes of adipose tissue and liver cells. Results: 1. Compared with the control group, the GBB4 group was significantly lower in body weight, weight of adipocytes, and amount of glucose. 2. The GBB4 group was significantly lower in the amount of total cholesterol, LDL-cholesterol and triglycerides, and HDL-cholesterol compared with the control. 3. Compared with the control group, the GBB4 group was significantly lower in the amount of serum leptin. 4. The GBB4 group was significantly higher in the revelation of ${\beta}3AR$ and leptin in 3T3-L1 adipocytes and primary adipose cells compared with the control. 5. Compared with the control group, the GBB4 group was smaller in the size of adipocytes in adipose tissue and the adipose vacuoles in liver tissue were decreased. Conclusions: These results suggested that GBB4 has inhibitory effects on obesity. GBB4 might be applied in treatment of obesity, so further studies analyzing its effects are needed.

Keywords

References

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