Korean Journal of Pharmacognosy (생약학회지)

The Korean Society of Pharmacognosy (한국생약학회)
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Screening on Receptor Tyrosine Kinase Inhibitory Activity of Marine Algae-Derived Symbiotic Microorganisms

해조류 공생미생물의 Receptor Tyrosine Kinase 억제효능 검색

  • Yun, Keum-Ja (Department of Chemistry, Pukyong National University) ;
  • Yang, Guohua (Department of Chemistry, Pukyong National University) ;
  • Feng, Zhile (Department of Chemistry, Pukyong National University) ;
  • Nenkep, Viviane N. (Department of Chemistry, Pukyong National University) ;
  • Xavier, Siwe-Noundou (Department of Chemistry, Pukyong National University) ;
  • Leutou, Alain S. (Department of Chemistry, Pukyong National University) ;
  • Kim, Gun-Do (Department of Microbiology, Pukyong National University) ;
  • Cho, Hee-Yeong (Pharmacology Research Center, Korea Research Institute of Chemical Technology) ;
  • Choi, Hong-Dae (Department of Chemistry, Dongeui University) ;
  • Son, Byeng-Wha (Department of Chemistry, Pukyong National University)
  • Received : 2010.01.23
  • Published : 2010.03.31
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Abstract

In order to screen new receptor tyrosine kinase inhibitor which is expected to be anticancer drug lead, we have investigated receptor tyrosine kinase inhibitory activity on the marine alga-derived symbiotic microorganisms (500 strains). The significant activities (over 70% inhibition at $10\;{\mu}g/ml$) were observed in the extracts of ten strains (Strain No.: MFA018, 019, 206, 242, 325, 335, 343, 344, 354, 356), isolated from marine red algae, five strains (Strain No.: MFA030, 126, 213, 324, 339), isolated from the brown algae, and one strain (Strain No.: MFA272), isolated from the marine green algae, respectively. Among the active strains, MFA019 and 356 showed strong receptor tyrosine kinase inhibitory activity with $IC_{50}$ values of 0.6 and $0.9\;{\mu}g/ml$, respectively.

Keywords

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