Tuberculosis and Respiratory Diseases

The Korean Academy of Tuberculosis and Respiratory Diseases (대한결핵및호흡기학회)
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Bronchiolitis Obliterans Organizing Pneumonia in the Patient with Non-Small Cell Lung Cancer Treated with Docetaxel/Cisplatin Chemotherapy: A Case Report

Docetaxel과 Cisplatin으로 치료한 비소세포폐암환자에서 발생한 BOOP 1예

  • Kim, Ae-Ran (Department of Internal Medicine, Daedong Hospital) ;
  • Kim, Tae-Young (Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Pusan Paik Hospital, Inje University College of Medicine) ;
  • Lee, Young-Min (Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Pusan Paik Hospital, Inje University College of Medicine) ;
  • Lee, Seung-Heon (Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Pusan Paik Hospital, Inje University College of Medicine) ;
  • Jung, Soo-Jin (Department of Pathology, Pusan Paik Hospital, Inje University College of Medicine) ;
  • Lee, Hyun-Kyung (Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Pusan Paik Hospital, Inje University College of Medicine)
  • 김애란 (대동병원 내과) ;
  • 김태영 (인제대학교 의과대학 부산백병원 호흡기내과) ;
  • 이영민 (인제대학교 의과대학 부산백병원 호흡기내과) ;
  • 이승헌 (인제대학교 의과대학 부산백병원 호흡기내과) ;
  • 정수진 (인제대학교 의과대학 부산백병원 병리과) ;
  • 이현경 (인제대학교 의과대학 부산백병원 호흡기내과)
  • Received : 2010.05.18
  • Accepted : 2010.09.15
  • Published : 2010.10.30
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Abstract

A 60-year-old man was diagnosed with stage IV squamous cell carcinoma of lung and treated with weekly doses of docetaxel and cisplatin. Tumor mass and mediastinal lymphadenopathy disappeared after 4.5 cycles of chemotherapy. At one week post final chemotherapy, the patients developed sudden shortness of breath. New, multifocal infiltrations developed on both lungs without definitive evidence of infection. Despite administration of broad spectrum antibiotics, the lung lesion did not improve, so bronchoalveolar lavage and computed tomography-guided lung biopsy were performed. The proportion of lymphocytes was increased markedly and histopathology revealed squamous cell carcinoma combined with bronchiolitis obliterans organizing pneumonia. After high dose corticosteroid therapy, dyspnea and the newly developed consolidation had decreased slightly. However, dyspnea and hypoxemia increased again because of aggravated lung cancer since chemotherapy had stopped. Chemotherapy couldn't be restarted due to the poor performance status of the patient. Later, patient died of respiratory failure from poor general condition and progression of lung cancer.

Keywords

References

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