Tuberculosis and Respiratory Diseases

The Korean Academy of Tuberculosis and Respiratory Diseases (대한결핵및호흡기학회)
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Two Cases of Nontuberculous Mycobacterial Lung Disease in Heart Transplant Recipients

심장이식 환자에서 발생한 비결핵항산균 폐질환 2예

  • Jo, Jung-Min (Department of Internal Medicine, Asan Medical Center, University of Ulsan College of Medicine) ;
  • Shin, Mi-Seon (Department of Internal Medicine, Asan Medical Center, University of Ulsan College of Medicine) ;
  • Kim, Joo-Hui (Department of Internal Medicine, Asan Medical Center, University of Ulsan College of Medicine) ;
  • Kim, Min-Jung (Department of Internal Medicine, Asan Medical Center, University of Ulsan College of Medicine) ;
  • Park, Hyun-Jung (Department of Internal Medicine, Asan Medical Center, University of Ulsan College of Medicine) ;
  • Na, Hee-Kyung (Department of Internal Medicine, Asan Medical Center, University of Ulsan College of Medicine) ;
  • Jo, Kyung-Uk (Department of Pulmonary and Critical Care Medicine, Asan Medical Center, University of Ulsan College of Medicine) ;
  • Kim, Jae-Joong (Department of Cardiology, Asan Medical Center, University of Ulsan College of Medicine) ;
  • Shim, Tae-Sun (Department of Pulmonary and Critical Care Medicine, Asan Medical Center, University of Ulsan College of Medicine)
  • 조정민 (울산대학교 의과대학 서울아산병원 내과학교실) ;
  • 신미선 (울산대학교 의과대학 서울아산병원 내과학교실) ;
  • 김주희 (울산대학교 의과대학 서울아산병원 내과학교실) ;
  • 김민정 (울산대학교 의과대학 서울아산병원 내과학교실) ;
  • 박현정 (울산대학교 의과대학 서울아산병원 내과학교실) ;
  • 나희경 (울산대학교 의과대학 서울아산병원 내과학교실) ;
  • 조경욱 (울산대학교 의과대학 서울아산병원 호흡기내과학교실) ;
  • 김재중 (울산대학교 의과대학 서울아산병원 심장내과학교실) ;
  • 심태선 (울산대학교 의과대학 서울아산병원 호흡기내과학교실)
  • Received : 2010.03.16
  • Accepted : 2010.04.21
  • Published : 2010.09.30
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Abstract

Nontuberculous mycobacterial (NTM) diseases are increasing worldwide. However NTM lung disease in organ transplant recipients has been rarely reported. Here, we report 2 cases of NTM lung disease in heart transplant recipients. A 37-year-old man, who had undergone a heart transplant one year previous, was admitted to hospital due to a cough. Chest CT scan showed multiple centrilobular nodules in both lower lungs. In his sputum, M. abscessus was repeatedly identified by rpoB gene analysis. The patient improved after treatment with clarithromycin, imipenem, and amikacin. An additional patient, a 53-year-old woman who had undergone a heart transplant 4 years prior and who suffered from bronchiectasis, was admitted because of purulent sputum. The patient's chest CT scan revealed aggravated bronchiectasis; M. intracellulare was isolated repeatedly in her sputum. Treatment was successfully completed with clarithromycin, ethambutol, and ciprofloxacin. NTM lung disease should be considered as a potential opportunistic infection in organ transplant recipients.

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References

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