Communications for Statistical Applications and Methods

  • 제17권2호
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  • Pages.231-239
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  • 2010
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  • 2287-7843(pISSN)
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  • 2383-4757(eISSN)
한국통계학회 (The Korean Statistical Society)
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이질적 환경을 가지는 백신연구에서 백신효과 추정 방법의 비교연구

Comparative Study for Estimating Vaccine Efficacy in Vaccine Research under Heterogeneity

  • 투고 : 20091100
  • 심사 : 20100100
  • 발행 : 2010.03.31
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초록

백신연구에서 백신효과를 추정하기 위해 생존시간이 반복 관측되었지만 해석의 용이함과 모형의 편리성 때문에 일반적으로 첫 사건만을 고려한 비례위험모형을 사용해왔다. 그러나 이러한 방법은 실험체들의 감수성과 질병에 대한 노출정도가 이질적인 경우 정보의 손실을 초래할 뿐만 아니라 편향된 결과를 도출한다. 또한 반복 측정된 자료가 서로 독립적이기 보다 상호 연관되어 있을 가능성을 배제할 수 없다. 그러므로 본 연구에서는 시뮬레이션 연구를 통해 다양한 요소가 혼합된 복합적 상황에서 여러 통계적 모형을 이용하여 백신효과를 추정하는 방법들을 비교하였다.

In vaccine research, proportional hazards model including only first event have been widely used for estimating vaccine efficacy because it is easy to interpret and convenient. However, this method causes not only loss of information but also biased result when heterogeneity of study subject in exposure and susceptibility exists. Furthermore, it is hard to ignore the possibility that each event is correlated with each other in the repeated events. Therefore, we compare various statistical models to estimate vaccine efficacy under various situations with heterogeneity and event dependency.

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