The Journal of Internal Korean Medicine (대한한방내과학회지)

The Society of Internal Korean Medicine (대한한방내과학회)
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Effective Recruitment Strategies in Clinical Trials : An analysis of methods used in functional dyspepsia clinical trial

임상연구의 효과적인 대상자 모집 전략 - 기능성 소화불량증 임상시험 자료에 대한 분석 -

  • Jerng, Ui-Min (3rd Dept. of Internal Medicine, College of Oriental Medicine, Kyung-Hee University) ;
  • Ko, Seok-Jae (3rd Dept. of Internal Medicine, College of Oriental Medicine, Kyung-Hee University) ;
  • Han, Ga-Jin (3rd Dept. of Internal Medicine, College of Oriental Medicine, Kyung-Hee University) ;
  • Oh, Seung-Hwan (3rd Dept. of Internal Medicine, College of Oriental Medicine, Kyung-Hee University) ;
  • Kim, Jin-Sung (3rd Dept. of Internal Medicine, College of Oriental Medicine, Kyung-Hee University) ;
  • Ryu, Bong-Ha (3rd Dept. of Internal Medicine, College of Oriental Medicine, Kyung-Hee University) ;
  • Park, Jae-Woo (3rd Dept. of Internal Medicine, College of Oriental Medicine, Kyung-Hee University)
  • 정의민 (경희대학교 한의과대학 비계내과학 교실) ;
  • 고석재 (경희대학교 한의과대학 비계내과학 교실) ;
  • 한가진 (경희대학교 한의과대학 비계내과학 교실) ;
  • 오승환 (경희대학교 한의과대학 비계내과학 교실) ;
  • 김진성 (경희대학교 한의과대학 비계내과학 교실) ;
  • 류봉하 (경희대학교 한의과대학 비계내과학 교실) ;
  • 박재우 (경희대학교 한의과대학 비계내과학 교실)
  • Published : 2010.12.30
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Abstract

Objectives : While the proportion of clinical trials is increasing in oriental medical research, no studies in recruitment strategies exist. This study was conducted to investigate which recruitment strategy was efficient to increase the number of potential subject and to reduce cost. Methods : Data from 179 callers in a single-center between June 22 and August 12, 2010 were analyzed. Results : We found that daily newspaper and free newspaper advertisement collected maximal participants. Advertisements in the hospital and on the Internet were considered as the most cost-effective methods. Conclusions : Intensive multiple overlapping recruitment strategies might be effective in success of participant registration in a clinical trial.

Keywords

References

  1. 김건형, 김동일, 황덕상, 이진무, 김형준, 윤현민 등. 갱년 및 폐경 후 여성의 안면홍조에 대한 침치료 다기관 임상연구 : 수행보고 및 방법론적 교훈. 대한한방부인과학회지. 2010;23(1):42-52.
  2. 황선복, 박성민, 오민지, 김희택. 아토피 피부염 환자에 대한 위약 대조 시험법에 의한 'Atomento solution & cream'의 유효성 및 안전성을 평가하기 위한 단일기관, 무작위배정, 이중맹검, 위약대조, 비교 임상연구. 한방안이비인후피부과학회지. 2009;22(2):223-37.
  3. Chin Feman SP, Nguyen LT, Quilty MT, Kerr CE, Nam BH, Conboy LA et al. Effectiveness of recruitment in clinical trials: an analysis of methods used in a trial for irritable bowel syndrome patients. Contemp Clin Trials. 2008;29(2):241-51. https://doi.org/10.1016/j.cct.2007.08.004
  4. Adams J, Silverman M, Musa D, Peele P. Recruiting older adults for clinical trials. Control Clin Trials. 1997;18:14-26. https://doi.org/10.1016/S0197-2456(96)00132-8
  5. Anderson DL. A Guide To Patient Recruitment. Boston, Messachusetts, USA: CenterWatch/Thomson Healthcare; 2001.
  6. Bjornson-Benson WM, Stilbolt TB, Manske BA, Zavela KJ, Youtsey DJ, Buist AS. Monitoring recruitment effectiveness and cost in a clinical trial. Control Clin Trials 1993;14:52S-67S. https://doi.org/10.1016/0197-2456(93)90024-8
  7. Bielski RJ, Lydiard RB. Therapeutic trial participants : where do we find them and what does it cost? Psychopharmacol Bull. 1997;33:75-8.
  8. Pastore LM, Dalal P. Recruitment strategies for an acupuncture randomized clinical trial of reproductive age women. Complement Ther Med. 2009;17(4):229-35. https://doi.org/10.1016/j.ctim.2009.03.004
  9. Schroy PC 3rd, Glick JT, Robinson P, Lydotes MA, Heeren TC, Prout M et al. A costeffectiveness analysis of subject recruitment strategies in the HIPAA era: results from a colorectal cancer screening adherence trial. Clin Trials. 2009;6(6):597-609. https://doi.org/10.1177/1740774509346703
  10. Lovato LC, Hill K, Hertert S, Hunninghake DB, Probstfield JL. Recruitment for controlled clinical trials: literature summary and annotated bibliography. Control Clin Trials. 1997;18(4):328-52. https://doi.org/10.1016/S0197-2456(96)00236-X
  11. Patrick JH, Pruchno RA, Rose MS. Recruiting research participants: a comparison of the costs and effectiveness of five recruitment strategies. Gerontologist. 1998 Jun;38(3):295-302. https://doi.org/10.1093/geront/38.3.295
  12. Ross S, Grant A, Counsell C, Gillespie W, Russell I, Prescott R. Barriers to participation in randomised controlled trials: a systematic review. J Clin Epidemiol. 1999;52(12):1143-56. https://doi.org/10.1016/S0895-4356(99)00141-9
  13. Simes RJ, Tattersall MH, Coates AS, Raghavan D, Solomon HJ, Smartt H. Randomised comparison of procedures for obtaining informed consent in clinical trials of treatment for cancer. Br Med J. 1986;293(6554):1065-8. https://doi.org/10.1136/bmj.293.6554.1065