대한한방내과학회지 (The Journal of Internal Korean Medicine)

대한한방내과학회 (The Society of Internal Korean Medicine)
권호 표지

오피산(五皮散)이 Cisplatin으로 유발(誘發)된 흰쥐의 급성신부전(急性腎不全)에 미치는 영향(影響)

Nephroprotective Effects of Opi-san Aqueous Extracts on Cisplatin-induced Rat Acute Renal Failure

  • 김태우 (대구한의대학교 부속한방병원 신계내과학교실) ;
  • 윤경민 (대구한의대학교 부속한방병원 신계내과학교실) ;
  • 임은영 (대구한의대학교 부속한방병원 신계내과학교실) ;
  • 신현철 (대구한의대학교 부속한방병원 신계내과학교실) ;
  • 강석봉 (대구한의대학교 부속한방병원 신계내과학교실)
  • Kim, Tae-U (Dept. of Oriental Internal Medicine Graduate School, Deagu Haany University) ;
  • Yoon, Gyeong-Min (Dept. of Oriental Internal Medicine Graduate School, Deagu Haany University) ;
  • Im, Eun-Yeong (Dept. of Oriental Internal Medicine Graduate School, Deagu Haany University) ;
  • Shin, Hyeon-Chul (Dept. of Oriental Internal Medicine Graduate School, Deagu Haany University) ;
  • Kang, Seok-Bong (Dept. of Oriental Internal Medicine Graduate School, Deagu Haany University)
  • 발행 : 2010.09.30
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초록

Purpose : This study was to observe the nephroprotective effects of the traditional prescription, Opi-san(OPS). OPS has been generally used for treating various edematous renal diseases, including acute renal failure. Methods : Three different dosages of OPS extracts were administered once a day for 28 days (5 mg/kg, single intraperitoneally administered). On the 23rd day after OPS extract treatment, cisplatin was treated. All the rats (6 groups of 8 rats each) were checked as follows. Changes of body weight, kidney weight, serum BUN and creatinine levels were observed, as well as changes to the kidney MDA and GSH contents. The results were compared with captopril 100 mg/kg, of which the effects on cisplatin-induced acute renal failures were already confirmed. Results : Cisplatin-induced ARF were induced by oxidative stress and related lipid peroxidation in the present study. However, these ARF and inhibition of antioxidant effects induced by cisplatin were dose-dependently reduced by treatment of OPS extracts except in the 100 mg/kg treated group. The effects of OPS extracts at 500 mg/kg were similar to those of 100 mg/kg of captopril. Conclusion : This study suggests that OPS extracts 500 mg/kg showed favorable effects on the cisplatin-induced rat's ARF as similar to 100 mg/kg of captopril.

키워드

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