중풍환자에서 수족냉증과 적혈구변형능의 관련성 연구

The Relationship between Coldness of Hands and Feet and the Erythrocyte Deformability in Stroke Patients

  • 박주영 (경희대학교 한의과대학 한방순환신경내과) ;
  • 임정태 (경희대학교 한의과대학 한방순환신경내과) ;
  • 박수경 (경희대학교 한의과대학 한방순환신경내과) ;
  • 우수경 (경희대학교 한의과대학 한방순환신경내과) ;
  • 곽승혁 (경희대학교 한의과대학 한방순환신경내과) ;
  • 정우상 (경희대학교 한의과대학 한방순환신경내과) ;
  • 문상관 (경희대학교 한의과대학 한방순환신경내과) ;
  • 조기호 (경희대학교 한의과대학 한방순환신경내과) ;
  • 박성욱 (경희대학교 동서신의학병원 중풍.뇌질환센터) ;
  • 고창남 (경희대학교 동서신의학병원 중풍.뇌질환센터)
  • Park, Joo-Young (Dept. of Cardiovascular & Neurologic Disease(Stroke center), College of Oriental Medicine, Kyung-Hee University) ;
  • Leem, Jung-Tae (Dept. of Cardiovascular & Neurologic Disease(Stroke center), College of Oriental Medicine, Kyung-Hee University) ;
  • Park, Su-Kyung (Dept. of Cardiovascular & Neurologic Disease(Stroke center), College of Oriental Medicine, Kyung-Hee University) ;
  • Woo, Su-Kyung (Dept. of Cardiovascular & Neurologic Disease(Stroke center), College of Oriental Medicine, Kyung-Hee University) ;
  • Kwak, Seung-Hyuk (Dept. of Cardiovascular & Neurologic Disease(Stroke center), College of Oriental Medicine, Kyung-Hee University) ;
  • Jung, Woo-Sang (Dept. of Cardiovascular & Neurologic Disease(Stroke center), College of Oriental Medicine, Kyung-Hee University) ;
  • Moon, Sang-Kwan (Dept. of Cardiovascular & Neurologic Disease(Stroke center), College of Oriental Medicine, Kyung-Hee University) ;
  • Cho, Ki-Ho (Dept. of Cardiovascular & Neurologic Disease(Stroke center), College of Oriental Medicine, Kyung-Hee University) ;
  • Park, Sung-Wook (Stroke & Neurological disorders center, East-West Neo Medical Center, College of Oriental Medicine, Kyung-Hee University) ;
  • Ko, Chang-Nam (Stroke & Neurological disorders center, East-West Neo Medical Center, College of Oriental Medicine, Kyung-Hee University)
  • 발행 : 2010.09.30

초록

Objectives : Coldness of hands and feet has been regarded to be associated with blood circulation. This study was performed to assess the correlation between erythrocyte deformability and coldness of hands and feet. Methods : 145 patients who had taken an erythrocyte deformability test were selected for this study among hospitalized patients within 4 weeks after their cerebral infarction at the Internal Medical Department at Kyunghee Oriental Medical Center from August 2008 to August 2009. We divided the selected patients into two groups, with and without of coldness of hands and feet groups. The two groups were compared on risk factors for atherosclerosis and examined for variables including erythrocyte deformability. Results : 1. On demographic variables of the patients, only body mass index was significantly lower in the coldness of hands and feet group than the control group. There was no significant difference of the rate of hypertension, diabetes mellitus, hyperlipidemia, ischemic heart disease, smoking, drinking and carotid artery stenosis between the two groups. 2. According to blood test, the coldness of hands and feet group showed significantly lower erythrocyte deformability index than the control group. 3. Body mass index and erythrocyte deformability index showed a close relationship with coldness of hands and feet in multivariate analysis. Conclusions : The correlation between the erythrocyte deformability and coldness of hands and feet in cerebral infarction patients were decreased erythrocyte deformability participated in the mechanism of coldness of hands and feet.

키워드

참고문헌

  1. The societyof Modern Health Research. Comprehensive Cold Hypersensitivity Treatment Method. Seoul: Jinhwadang; 1994, p. 7-8, 101-2, 110-23, 135-9.
  2. 이상엽. 레이노 현항; 가정의학 임상편. 초판. 서울: 계축문화사; 2002, p. 628-33.
  3. 문준전 외. 상한론정해. 서울: 경희대학교 출판국; 1996, p. 568, 608.
  4. Maricq HR, Weinrich MC, Keil JE, et al. Prevalence of scleroderma spectrum disorders in the general population of South Carolina. Arthritis Rheum 1989;32:998-1006. https://doi.org/10.1002/anr.1780320809
  5. 최환석, 옥선명, 변준희 등. 수족부 감각이상자에서 레이노병의 유병률. 가정의학회지. 2003;24(12):1085-91.
  6. 김철민, 옥선명, 정주혜 등. 수족냉증과 레이노병에 대한 일부 가정의의 인식도. 대한가정의학회지. 2007;28:339-45.
  7. L.Dintenfass. Hyperviscosity and Hyperviscosemia. MTP Press, Lancester. 1985.
  8. Steven S.Segal. Regulation of Blood Flow in the Microcirculation. Microcirculation. 2005;12(1):33-45. https://doi.org/10.1080/10739680590895028
  9. H.H.Lipowsky. Microvascular rheology and hemodynamics. Microcirculation. 2005;12(1):5-15. https://doi.org/10.1080/10739680590894966
  10. O.K.Baskurt et al.Handbook of Hemorheology and Hemodynamics. ISO Press. 2007;34-71.
  11. S.Simchon, K.M.Jan and S.Chien, Influence of Reduced Red-Cell Deformability on Regional Blood-Flow, Am. J.Physiol. 1987;253:H898-H903.
  12. A.L.Herrick. Pathogenesis of Raynaud's phenomenon. Rheumatology. 2005;44:587-96. https://doi.org/10.1093/rheumatology/keh552
  13. Seh-yun Shin, Yun-He Ku, Jian-Xun Ho, Yu-Kyung Kim, Jang-So Suh, M. Singh. Progresive impairment of erythrocyte deformability as indicator of microangiography in type 2 diabetes melitus. Clinical Hemorheology and Microcirculation. 2007; 36:253-6
  14. Qiao Yang, Hirozo Goto, Hiroaki Hikiami. et al. Effects of Toki-shakuyaku-san on microcirculation of bulbar conjunctiva and hemorheological factor in patients with asymptomatic cerebral infarction. J.Trad.Med. 2004;21:170-73.
  15. 김동현, 김유경, 원동일, 신세현, 서장수. Ektacytometer를 이용한 tert-Butyl Hydroperoxide, Verapamil 및 Ascorbate 처리 적혈구의 혈액유변학적 변형능 측정. 대한진단검사의학회지. 2008;28(5):325-31.
  16. Seh-yun Shin, Yun-Hee Ku, Jang-Soo Suh, M. Singh. Rheological characteristics of erythrocytes incubated in glucose media. Clinical Hemorheology and Microcirculation. 2008;38:153-61.
  17. S. Shin, J. X. Hou, J. S. Suh, M. Singh. Validation and application of a microfluidic ektacytometer (RheoScan-D) in measuring erythrocyte Deformability. Clinical Hemorheology and Microcirculation. 2007; 37:319-28.
  18. Seventh Report of the Joint National Committee on the Prevention, Detection, Evaluation, and Treatment of High Blood Pressure, 2003.
  19. American Diabetes Association. Report of the expert committee on the Diagnosis and classification of Diabetes Mellitus. Diabetes Care. 1997;20: 1183-97. https://doi.org/10.2337/diacare.20.7.1183
  20. Executive Summary of the Third Report of the National Cholesterol Education Program (NECP) Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel III). JAMA. 2001;285: 2486-97. https://doi.org/10.1001/jama.285.19.2486