괴화산(槐花散)이 Dextran Sulfate Sodium으로 유도된 생쥐의 궤양성 대장염에 미치는 영향

Effects of Goihwa-san on Ulcerative Colitis Induced by Dextran Sulfate Sodium in Mice

  • 배광호 (세명대학교 한의과대학 부속 충주한방병원 내과학교실) ;
  • 공경환 (세명대학교 한의과대학 부속 충주한방병원 내과학교실)
  • Bae, Kwang-Ho (Dept. of Internal Medicine, Oriental Medical College, Se-Myung University) ;
  • Kong, Kyung-Hwan (Dept. of Internal Medicine, Oriental Medical College, Se-Myung University)
  • 발행 : 2010.09.30

초록

Objectives : This study was carried out to investigate the effects of Goihwa-san(GHS) against ulcerative colitis induced by DSS (dextran sulfate sodium). Method : The sample group was divided into three. The control group consisted of mice that were not inflammation-induced. The pathological group was composed of untreated colitis elicited mice. The experimental group was administered GHS after colitis elicitation. The effects on ulcerative colitis were evaluated by the morphological change of colonic mucosa, the anti-oxidant effect, HSP 70, NF-${\kappa}$B, COX-1, COX-2 and iNOS. Results : In terms of immunohistochemical changes, the distribution of COX-1 in mice treated with GHS increased noticeably more than that in the pathological group. The distributions of HSP70, NF-${\kappa}$B, COX-2, iNOS in mice treated with GHS more decreased than those in the pathological group. Regeneration of surface epithelial cell and goblet cell in mucosa was observed by optical microscope. The colonic lengths in GHS-treated mice were more elongated than those of DSS only treated mice. Conclusion : GHS is a candidate treatment for ulcerative colitis.

키워드

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