Advances in Traditional Medicine

Kyung Hee Oriental Medicine Research Center (경희대학교 융합한의과학연구소)
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Effects of Vitex rotundifolia on radical scavenging and nitric oxide production

  • Choi, Jae-Ki (Department of Oriental Pharmacy, College of Pharmacy, Woosuk University) ;
  • Cha, Dong-Seok (Department of Oriental Pharmacy, College of Pharmacy, Woosuk University) ;
  • Lee, Yong-Jae (Department of Oriental Pharmacy, College of Pharmacy, Woosuk University) ;
  • Ko, Sung-Hoon (Department of Oriental Pharmacy, College of Pharmacy, Woosuk University) ;
  • Park, Ho-Jun (Department of Oriental Pharmacy, College of Pharmacy, Woosuk University) ;
  • Lee, Se-Yeoun (Department of Oriental Pharmacy, College of Pharmacy, Woosuk University) ;
  • Choi, Jae-Hyuk (Department of Oriental Pharmacy, College of Pharmacy, Woosuk University) ;
  • Jeon, Hoon (Department of Oriental Pharmacy, College of Pharmacy, Woosuk University)
  • Received : 2010.03.10
  • Accepted : 2010.04.14
  • Published : 2010.06.30
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Abstract

Vitex rotundifolia (V. rotundifolia) has been used for treating headache, dizziness, toothache and removal of fever as a traditional medicine in Korea. In the present study, we examined the antioxidant and anti-inflammatory activities of 85% methanol extract of V. rotundifolia. In various radical scavenging assays, V. rotundifolia exhibited strong scavenging effect on 1, 1-diphenyl-2-picrylhydrazyl free radical, superoxide radical, nitric oxide. To elucidate the anti-inflammatory properties of V. rotundifolia, we investigated the inhibition effects of nitric oxide production in IFN-gamma and LPS-stimulated mouse peritoneal macrophages. V. rotundifolia suppressed nitric oxide production, iNOS and COX-2 expression dose-dependently through suppression of NF-$\hat{e}B$ activation without notable cytotoxicity. These findings mean that V. rotundifolia may be beneficial in oxidative stress-mediated inflammatory disorders.

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