Central Giant Cell Granuloma of the Mandible: A Case Report

하악에 발생한 중심성 거대세포육아종의 치험례

  • Chung, Jin-Wook (Departments of Plastic Surgery, College of Medicine, The Catholic University of Korea) ;
  • Oh, Deuk-Young (Departments of Plastic Surgery, College of Medicine, The Catholic University of Korea) ;
  • Seo, Je-Won (Departments of Plastic Surgery, College of Medicine, The Catholic University of Korea) ;
  • Moon, Suk-Ho (Departments of Plastic Surgery, College of Medicine, The Catholic University of Korea) ;
  • Lee, Jung-Ho (Departments of Plastic Surgery, College of Medicine, The Catholic University of Korea) ;
  • Rhie, Jong-Won (Departments of Plastic Surgery, College of Medicine, The Catholic University of Korea) ;
  • Ahn, Sang-Tae (Departments of Plastic Surgery, College of Medicine, The Catholic University of Korea) ;
  • Kim, Chang-Hyun (Departments of Oral and Maxillofacial Surgery, College of Medicine, The Catholic University of Korea)
  • 정진욱 (가톨릭대학교 의과대학 성형외과학교실) ;
  • 오득영 (가톨릭대학교 의과대학 성형외과학교실) ;
  • 서제원 (가톨릭대학교 의과대학 성형외과학교실) ;
  • 문석호 (가톨릭대학교 의과대학 성형외과학교실) ;
  • 이중호 (가톨릭대학교 의과대학 성형외과학교실) ;
  • 이종원 (가톨릭대학교 의과대학 성형외과학교실) ;
  • 안상태 (가톨릭대학교 의과대학 성형외과학교실) ;
  • 김창현 (가톨릭대학교 의과대학, 구강악안면외과학교실)
  • Received : 2010.04.27
  • Accepted : 2010.07.12
  • Published : 2010.09.10

Abstract

Purpose: Central giant cell granuloma is a rare, benign giant cell tumor which commonly develops in areas near the teeth. It accounts for approximately less than 7% of benign tumors of the mandible. Clinically, central giant cell granuloma is classifed into aggressive and non-aggressive type, and usually requires surgical treatment. There has been no report of central giant cell granuloma in plastic surgery field of the country, and we report a case with a brief review of the diagnosis and treatment of the disease. Methods: A 23-year-old male presented with a hard, non-tender, growing mass with the size of $4.0{\times}3.0\;cm$ on mandible for several months. Computed tomography scan showed a solid mass within thinned outer cortex on mandible. The thinned outer cortex was excised with the mass and the inner cortex was partially removed burring. After the tumor removal, mandible was fixed by reconstruction plate. Results: Pathologic report showed numerous large multinucleated giant cells, diffusely distributed in a background of ovoid-to-spindle-shaped mononuclear cells. There was no evidence of recurrence after 1 year follow up. Bony defect was regenerated and we removed the reconstruction plate. Conclusion: Removal of central giant cell granuloma results in defect of outer cortex, which can be reconstructed by using reconstruction plate, autologous bone graft or bone cement. We used reconstruction plate as a conservative method to induce secondary healing of the outer cortical defect area, which resulted in normal mastication and occlusion with no recurrence.

Keywords

References

  1. Kruse-Losler B, Diallo R, Gaertner C, Mischeke KL, Joos U, Kleinheinz J: Central giant cell granuloma of the jaws: a clinical, radiologic, and histopathologic study of 26 cases. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 101: 346, 2006 https://doi.org/10.1016/j.tripleo.2005.02.060
  2. Bataineh AB, Al-Khateeb T, Rawashdeh MA: The surgical treatment of central giant cell granuloma of the mandible. J Oral Maxillofac Surg 60: 756, 2002 https://doi.org/10.1053/joms.2002.33241
  3. Tosco P, Tanteri G, Iaquinta C, Fasolis M, Roccia F, Berrone S, Garzino-Demo P: Surgical treatment and reconstruction for central giant cell granuloma of the jaws: a review of 18 cases. J Craniomaxillofac Surg 37: 380, 2009 https://doi.org/10.1016/j.jcms.2009.04.002
  4. de Lange J, van den Akker HP, van den Berg H: Central giant cell granuloma of the jaw: a review of the literature with emphasis on therapy options. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 104: 603, 2007 https://doi.org/10.1016/j.tripleo.2007.04.003
  5. Granite EL, Aronoff AK, Gold L: Central giant cell granuloma of the mandible. a case report. Oral Surg Oral Med Oral Pathol 53: 241, 1982 https://doi.org/10.1016/0030-4220(82)90297-3
  6. De Corso E, Politi M, Marchese MR, Pirronti T, Ricci R, Paludetti G: Advanced giant cell reparative granuloma of the mandible: radiological features and surgical treatment. Acta Otorhinolaryngol Ital 26: 168, 2006
  7. Lee EE, Cha IH, Choi WH: Central giant cell granuloma in mandible: report of a case. J Korean Assoc Maxillofac Plast Reconstr Surg 13: 428, 1991
  8. Farrier S, Farrier JN, Smart MK, Nash ES: A 10-year review of the occurrence and treatment of central giant cell granulomas, in a distric general hospital. J Oral Parhol Med 35: 332, 2006 https://doi.org/10.1111/j.1600-0714.2006.00384.x