YAKHAK HOEJI (약학회지)

The Pharmaceutical Society of Korea (대한약학회)
권호 표지

Suppression of Induced Mucin Production from Human Airway Epithelial Cells by Coumarin and Indomethacin

쿠마린과 인도메타신의 억제작용 쿠마린과 인도메타신의 억제작용

  • Lee, Jae-Woo (LG Life Science) ;
  • Kim, Kil-Dong (Department of Thoracic Surgery, College of Medicine, Chungnam National University) ;
  • Jeon, Byeong-Kyou (Department of Radiologic Technology, Daegu Health College) ;
  • Lee, Choong-Jae (Department of Pharmacology, College of Medicine, Chungnam National University)
  • 이재우 (엘지 생명과학) ;
  • 김길동 (충남대학교 의과대학 흉부외과학교실) ;
  • 전병규 (대구보건대학 방사선과) ;
  • 이충재 (충남대학교 의과대학 약리학교실)
  • Received : 2010.07.22
  • Accepted : 2010.10.07
  • Published : 2010.10.31
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Abstract

We examined whether indomethacin, noscapine, coumarin, uridine and betaine affect airway mucin production induced by EGF or TNF-${\alpha}$ from NCI-H292 cells. Cells were pretreated with each agent for 30 min and then stimulated with EGF or TNF-${\alpha}$ for 24 h. Of the five compounds, coumarin suppressed airway mucin production induced by EGF or TNF-${\alpha}$. However, indomethacin suppressed airway mucin production induced by EGF. This result suggests that coumarin and indomethacin can regulate the production of mucin induced by EGF, by directly acting on airway epithelial cells.

Keywords

References

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