Journal of Microbiology and Biotechnology

The Korean Society for Microbiology and Biotechnology (한국미생물·생명공학회)
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The Effect of Protectants and pH Changes on the Cellular Growth and Succinic Acid Yield of Mannheimia succiniciproducens LPK7

  • Oh, Young-Hoon (Department of Chemical and Biomolecular Engineering, Sogang University) ;
  • Oh, In-Jae (Department of Chemical and Biomolecular Engineering, Sogang University) ;
  • Jung, Chang-Kyou (Department of Chemical and Biomolecular Engineering, Sogang University) ;
  • Lee, Sang-Yup (Department of Chemical and Biomolecular Engineering, Korea Advanced Institute of Science and Technology) ;
  • Lee, Jin-Won (Department of Chemical and Biomolecular Engineering, Sogang University)
  • Received : 2010.03.18
  • Accepted : 2010.08.30
  • Published : 2010.12.28
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Abstract

The harmful effects of succinic acid and oxidative stress on cell growth were determined during batch fermentation with Mannheimia succiniciproducens LPK7, a powerful succinic acid-producing strain, and conditions were optimized to minimize these effects. In terms of toxicity, the cell concentration decreased as the concentration of succinic acid increased. By changing the pH from 6.5 to 7 during fermentation, the cell concentration increased by about 10%, and the level of succinic acid production was 6% higher than that of the control. In addition, by introducing protectants, the cell concentration increased by about 10%, and the level of succinic acid produced was increased by 3%.

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References

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