Maxillofacial Plastic and Reconstructive Surgery

Korean Association of Maxillofacial Plastic and Reconstructive Surgeons (대한악안면성형재건외과학회)
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Bisphosphonate Related Osteonecrosis of Jaw on Mandibular Molar Area: a Case Report

하악 구치부에 발생한 Bisphosphonate Related Osteonecrosis of Jaw의 치험례

  • Park, Jae-An (Department of Oral and Maxillofacial Surgery, Sanggye Paik Hospital, Inje University) ;
  • Yoon, Kyu-Ho (Department of Oral and Maxillofacial Surgery, Sanggye Paik Hospital, Inje University) ;
  • Cheong, Jeong-Kwon (Department of Oral and Maxillofacial Surgery, Sanggye Paik Hospital, Inje University) ;
  • Bae, Jung-Ho (Department of Oral and Maxillofacial Surgery, Sanggye Paik Hospital, Inje University) ;
  • You, Kyung-Ha (Department of Oral and Maxillofacial Surgery, Sanggye Paik Hospital, Inje University) ;
  • Jo, Kyu-Hong (Department of Oral and Maxillofacial Surgery, Sanggye Paik Hospital, Inje University) ;
  • Shin, Jae-Myung (Department of Oral and Maxillofacial Surgery, Ilsan Paik Hospital, Inje University) ;
  • Baik, Jee-Seon (Department of Oral and Maxillofacial Surgery, Ilsan Paik Hospital, Inje University)
  • 박재안 (인제대학교 상계백병원 구강악안면외과학교실) ;
  • 윤규호 (인제대학교 상계백병원 구강악안면외과학교실) ;
  • 정정권 (인제대학교 상계백병원 구강악안면외과학교실) ;
  • 배정호 (인제대학교 상계백병원 구강악안면외과학교실) ;
  • 유경하 (인제대학교 상계백병원 구강악안면외과학교실) ;
  • 조규홍 (인제대학교 상계백병원 구강악안면외과학교실) ;
  • 신재명 (인제대학교 일산백병원 구강악안면외과학교실) ;
  • 백지선 (인제대학교 일산백병원 구강악안면외과학교실)
  • Received : 2010.04.16
  • Accepted : 2010.07.23
  • Published : 2010.09.30
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Abstract

Bisphosphonates are synthetic analogue and have high affinity on bone remodeling site. Since they have a long half-reduction time, they accumulate at bone and act for a long time. They are widely used in osteo-porosis derived from imflammatory bowel disease or postmenopausal osteoporosis patient for bone mineral density improvement. In addition, they neutralize hypercalcemia owing to bone metastasis of malignancy. However, a jaw bone necrosis was recently reported in some patients who have taken bisphosphonates for a long time. It is called Bisphosphonate Related Osteonecrosis of Jaws (BRONJ). It can come spontaneous-ly, but more often after oral surgery including tooth extraction. In this case, a 80-year-old woman was treated with bisphosphonate (sodium alendronate) for 2 years to improve bone mineral density. She had her left lower second molar tooth extracted at local clinic. After extraction, she had inflammatory symptoms like a pain, a cheek swelling, and a discharge of pus. She was referred to our clinic for treatment. We treated meticulously from dressing to surgery. After following up about 1.5 years, the jaw lesion was successfully healed. So we report this case.

Keywords

References

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