Clinical and Experimental Pediatrics

대한소아청소년과학회 (The Korean Pediatric Society)
권호 표지
DOI QR코드

DOI QR Code

The effect of sucrose on infants during a painful procedure

  • 투고 : 2010.03.06
  • 심사 : 2010.07.13
  • 발행 : 2010.08.15
PDF 다운로드
⟨ 이전 논문 다음 논문 ⟩

초록

Purpose: The purpose of this study was to test the efficacy of treating the pain among newborn infants associated with a medical procedure with sucrose with regard to overall physiological and behavioral stability. Methods: 103 newborn infants were enrolled in this study. The control group (n=63) did not receive any treatment. The experimental group (n=40) received 2 mL of 24% sucrose solution two minutes before a routine heel stick. The pain was assessed by measurements of physiological changes [e.g. pulse rate, oxygen saturation, salivary cortisol (hydrocortisone)] and behavioral changes [e.g. crying time, and the neonatal infant pain scale (NIPS) for neonates]. Results: There were no differences among the groups with respect to physiological changes associated with the pain from the procedure. However, there were significant group differences in behavioral changes to the pain. In the control group, the median crying time was 13 seconds, while in the experimental group, the median crying time was 3.5 seconds ($P$=.000). In the control group the median NIPS score was 4, while in the experimental group the median NIPS score was 2 ($P$=.000). Conclusions: These findings suggest that sucrose can be an effective method for the management of stress responses in infants with regard to behavior. However, this treatment had no significant physiological effects.

키워드

참고문헌

  1. Carbajal R, Chauvet X, Couderc S, Olivier-Martin M. Randomized trial of analgesic effects of sucrose, glucose and pacifiers in term neonates. BMJ 1999;319:1393-7. https://doi.org/10.1136/bmj.319.7222.1393
  2. Anand KJ; International Evidence-Based Group for Neonatal Pain. Consensus statement for the prevention and management of pain in the newborn. Arch Pediatr Adolesc Med 2001;155:173-80. https://doi.org/10.1001/archpedi.155.2.173
  3. Elserafy FA, Alsaedi SA, Louwrens J, Bin Sadiq B, Mersal AY. Oral sucrose and a pacifier for pain relief during simple procedures in preterm infants: a randomized controlled trial. Ann Saudi Med 2009;29:184-8. https://doi.org/10.5144/0256-4947.52821
  4. Mitchell A, Stevens B, Mungan N, Johnson W, Lobert S, Boss B. Analgesic effects of oral sucrose and pacifier during eye examinations for retinopathy of prematurity. Pain Manag Nurs 2004;5:160-8. https://doi.org/10.1016/j.pmn.2004.06.001
  5. Blass E, Fitzgerald E, Kehoe P. Interactions between sucrose, pain and isolation distress. Pharmacol Biochem Behav 1987;26:483-9. https://doi.org/10.1016/0091-3057(87)90153-5
  6. American Academy of Pediatrics, Committee on Psychosocial Aspects of Child and Family Health; American Pain Society, Task Force on Pain in Infants, Children, and Adolescents. The assessment and management of acute pain in infants, children, and adolescents. Pediatrics 2001;108:793-7. https://doi.org/10.1542/peds.108.3.793
  7. Stevens B, Yamada J, Ohlsson A. Sucrose for analgesia in newborn infants undergoing painful procedure. Cochrane Database Syst Rev 2010;20:CD001069.
  8. Herrington CJ, Olomu IN, Geller SM. Salivary cortisol as indicators of pain in preterm infants: a pilot study. Clin Nurs Res 2004;13:53-68. https://doi.org/10.1177/1054773803259665
  9. Nelson N, Arbring K, Theodorsson E. Neonatal salivary cortisol in response to heelstick: method modifications enable analysis of low concentrations and small sample volumes. Scand J Clin Lab Invest 2001;61:287-91. https://doi.org/10.1080/00365510152379012
  10. Ng PC. Is there a "Normal" range of serum cortisol concentration for preterm infants? Pediatrics 2008;122:873-5. https://doi.org/10.1542/peds.2008-0516
  11. Rokicki W, Forest MG, Loras B, Bonnet H, Bertrand J. Free cortisol of human plasma in the first three months of life. Biol Neonate 1990;57:21-9. https://doi.org/10.1159/000243148
  12. Joung KH, Cho SC. Stress responses of neonates related to maternal characteristics. Yonsei Med J. In press 2010. https://doi.org/10.3349/ymj.2011.52.1.98
  13. Boyer K, Johnston C, Walker CD, Filion F, Sherrard A. Does sucrose analgesia promote physiologic stability in preterm neonates? Biol neonate 2004;85:26-31. https://doi.org/10.1159/000074954
  14. Greenberg CS. A sugar-coated pacifier reduces procedural pain in newborns. Pediatr Nurs 2002;28:271-7.
  15. Lawrence J, Alcock D, McGrath P, Kay J, MacMurray SB, Dulberg C. The development of a tool to assess neonatal pain. Neonatal Netw 1993;12:59-66.
  16. Gibbins S, Stevens B, McGrath PJ, Yameda J, Beyene J, Breau L, et al. Comparison of pain responses in infants of different gestational ages. Neonatology 2008;93:10-8. https://doi.org/10.1159/000105520
  17. Schaffer L, Muller-Vizentini D, Burkhardt T, Rauh M, Ehlert U, Beinder E. Blunted stress response in small for gestational age neonates. Pediatr Res 2009;65:231-5. https://doi.org/10.1203/PDR.0b013e318191fb44
  18. Ng PC. The fetal and neonatal hypothalamic-pituitary-adrenal axis. Arch Dis Child Fetal Neonatal Ed 2000;82:F250-4. https://doi.org/10.1136/fn.82.3.F250
  19. Gunnar MR, Talge NM, Herrera A. Stressor paradigms in developmental studies: what does and does not work to produce mean increases in salivary cortisol. Psychoneuroendocrinology 2009;34:953-67. https://doi.org/10.1016/j.psyneuen.2009.02.010
  20. Johnston CC, Stremler RL, Stevens BJ, Horton LJ. Effectiveness of oral sucrose and simulated rocking on pain response in preterm neonates. Pain 1997;72:193-9. https://doi.org/10.1016/S0304-3959(97)00033-X

피인용 문헌

  1. Nonpharmacologic Pain Relief with Oral 25% Dextrose or/and Pacifier for Newborn Infants vol.18, pp.2, 2010, https://doi.org/10.5385/jksn.2011.18.2.353
  2. The Ethics of Pain Clinical Trials on Persons Lacking Judgment Ability: Much to Improve vol.13, pp.3, 2012, https://doi.org/10.1111/j.1526-4637.2011.01325.x
  3. Medication Repurposing in Pediatric Patients: Teaching Old Drugs New Tricks vol.21, pp.1, 2016, https://doi.org/10.5863/1551-6776-21.1.36