Bulletin of the Korean Chemical Society

Korean Chemical Society (대한화학회)
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An Efficient Synthesis of 3,4-Dihydro-3-substituted-2H-naphtho[2,1-e][1,3]oxazine Derivatives Catalyzed by Zirconyl(IV) Chloride and Evaluation of its Biological Activities

  • Kategaonkar, Amol H. (Department of Chemistry, Dr. Babasaheb Ambedkar Marathwada University) ;
  • Sonar, Swapnil S. (Department of Chemistry, Dr. Babasaheb Ambedkar Marathwada University) ;
  • Pokalwar, Rajkumar U. (Department of Chemistry, Dr. Babasaheb Ambedkar Marathwada University) ;
  • Kategaonkar, Atul H. (Pharmacology Laboratory, Maharashtra Institute of Pharmacy) ;
  • Shingate, Bapurao B. (Department of Chemistry, Dr. Babasaheb Ambedkar Marathwada University) ;
  • Shingare, Murlidhar S. (Department of Chemistry, Dr. Babasaheb Ambedkar Marathwada University)
  • Received : 2010.02.20
  • Accepted : 2010.04.02
  • Published : 2010.06.20
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Abstract

An efficient and novel one-pot synthesis of new 3,4-dihydro-3-substituted-2H-naphtho[2,1-e][1,3]oxazine derivatives from 1-naphthol, various anilines and formalin at room temperature grinding is presented. The six-membered N,O-heterocyclic skeleton was constructed via zirconyl(IV) chloride promoted Mannich type reaction. In vitro antimicrobial activities of synthesized compounds have been investigated against Gram-positive Bacillus subtilis, Gram negative Escherichia coli and two fungi Candida albicans and Aspergillus niger in comparison with standard drugs. The results of preliminary bioassay indicate that some of title compounds possess significant antibacterial and antifungal activity.

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References

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