Bulletin of the Korean Chemical Society

Korean Chemical Society (대한화학회)
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The Synthesis of Diverse Adenosine 5'-phosphonate Analogues as Chain Terminators against Hepatitis C Virus (HCV)

  • Kim, Bo-Seung (Department of Bioactive Material Sciences, College of Natural Science, Chonbuk National University) ;
  • Kim, Beom-Tae (Department of Bioactive Material Sciences, College of Natural Science, Chonbuk National University) ;
  • Hwang, Ki-Jun (Department of Chemistry, Chonbuk National University)
  • Received : 2010.03.02
  • Accepted : 2010.03.29
  • Published : 2010.06.20
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Abstract

Adenosine 5'-phosphonates have been reported as potential chain terminators against Hepatitis C virus (HCV); therefore, we developed convenient sequences for synthesis of modified adenosine 5'-phosphonates in which the hydroxyl group at 2' or 3'-position of the sugar moiety is substituted with the azido or amino group and the oxymethyl group at the 4'-position is modified by the ethylene or vinyl group. This synthetic sequence can provide six adenosine 5'-phosphonates via one protocol, and is considered to be very efficient and a convenient route of synthesis. An assay of adenosine 5'-phosphonate analogues (1, 2, 3, 4, 5, and 6) against HCV infection is now in progress.

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References

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