Korean Journal of Health Education and Promotion (보건교육건강증진학회지)

Korean Society for Health Education and Promotion (한국보건교육건강증진학회)
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Risk Factors Associated with HPV Infection in the Female Employees and Employees' Partner

여성 직장인 및 직장인 배우자의 인유두종 바이러스 감염 위험인자

  • Jang, Tae-Won (Department of Occupational & Environmental Medicine, Hangang Sacred Heart Hospital, Hallym University) ;
  • Yoon, Ki-Jung (Department of Occupational and Environmental Medicine, Kangbuk Samsung Hospital, School of Medicine, Sungkyunkwan University)
  • 장태원 (한림대학교 한강성심병원 산업의학과) ;
  • 윤기정 (성균관대학교 의과대학 강북삼성병원 산업의학과)
  • Received : 2009.10.07
  • Accepted : 2010.03.13
  • Published : 2010.03.31
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Abstract

Objectives: Human papillomavirus (HPV) infection is highly associated with cervical cancer. So, the modification of the risk factors of HPV infection is essential for prevention of cervical cancer. This study was performed to evaluate the risk factors of HPV infection. Methods: HPV test of 12,337 study population conducted using Hybrid-Capture II assay(HC-II) and self-administered questionnaires were collected. The study population was people who visited hospital-based medical screening center from January to December 2007 and all were female employees or employees' partner. Results: In logistic regression analysis, smoking and alcohol drinking were significant factors, with odds ratios of 1.328 (95% CI 1.010~1.746) and 1.644 (95% CI 1.309~2.066), respectively. Nutritional supplements was also significant factor, which odds ratio was 1.161 (95% CI 1.004~1.343). Oral contraceptives was positive association with HPV infection (odds ratio 2.108; 95% CI 1.217~3.652), whereas condom was negative association (odds ratio 0.851; 95% CI 0.740~0.979). Conclusion: HPV Prevalence of 12,377 study population was 11.4%. Smoking, alcohol drinking, nutritional supplements and oral contraceptives were possible risk factors of HPV infection, and condom had possible preventive effect on HPV infection. Further prospective and comprehensive studies about HPV risk factors are required.

Keywords

References

  1. 보건복지부. 2003-2005년의 암 발생 통계와 1993-2005년의 암생존률. 서울: 보건복지부, 2008.
  2. 보건복지부. 한국인의 주요 질병과 건강행태에 관한 분석: 2001년 국가 건강과 영양조사의 심층분석. 서울: 보건복지부, 2003.
  3. 보건복지부. 한국 중앙 암 등록사업 보고서. 서울: 보건복지부, 2007.
  4. 손애리, 조병희. 전국 도시주민들의 콘돔사용 실태 및 콘돔사용에 영향을 미치는 요인. 한국보건통계학회지 2003;28(2):76-94.
  5. 오진경 외 5명. 일부 젊은 연령층의 인유두종바이러스(Human Papillomavirus) 감염 위험요인간의 관련성연구. 한국역학회지 2005;27(1):118-128.
  6. Centers for Disease Control and Prevention. Tracking the hidden epidemics: Trends in stds in the united states, 2000.
  7. Centers for Disease Control and Prevention. Youth risk behavior surveillance-united states, 2003.
  8. Clifford G, Franceschi S, Diaz M, Munoz N, Villa LL. Chapter 3: HPV type-distribution in women with and without cervical neoplastic diseases. Vaccine 2006;24 Suppl 3:S3/26-34.
  9. de Villiers EM, Fauquet C, Broker TR, Bernard HU, zur Hausen H. Classification of papillomaviruses. Virology 2004;324(1):17-27. https://doi.org/10.1016/j.virol.2004.03.033
  10. Dunne EF, Unger ER, Sternberg M, McQuillan G, Swan DC, Patel SS, et al. Prevalence of HPV infection among females in the United States. JAMA 2007;297(8):813-819. https://doi.org/10.1001/jama.297.8.813
  11. Giuliano AR, Sedjo RL, Roe DJ, Harri R, Baldwi S, Papenfuss MR, et al. Clearance of oncogenic human papillomavirus (HPV) infection: effect of smoking (United States). Cancer Causes 2002;13(9):839-846. https://doi.org/10.1023/A:1020668232219
  12. Giuliano AR, Siegel EM, Roe DJ, Ferreira S, Baggio ML, Galan L, et al. Dietary intake and risk of persistent human papillomavirus (HPV) infection: the Ludwig-McGill HPV Natural History Study. J Infect Dis 2003;188(10):1508-1516. https://doi.org/10.1086/379197
  13. Goodman MT, Kiviat N, McDuffie K, Hankin JH, Hernandez B, Wilkens LR, et al. The association of plasma micronutrients with the risk of cervical dysplasia in Hawaii. Cancer Epidemiol Biomarkers Prev 1998;7(6):537-544.
  14. Ho GY, Bierman R, Beardsley L, Chang CJ, Burk RD. Natural history of cervicovaginal papillomavirus infection in young women. N Engl J Med 1998;338(7):423-428. https://doi.org/10.1056/NEJM199802123380703
  15. Ho GY, Burk RD, Klein S, Kadish AS, Chang CJ, Palan P, et al. Persistent genital human papillomavirus infection as a risk factor for persistent cervical dysplasia. J Natl Cancer Inst 1995;87(18):1365-1371. https://doi.org/10.1093/jnci/87.18.1365
  16. Kenney JW. Risk factors associated with genital HPV infection. Cancer Nurs 1996;19(5):353-359. https://doi.org/10.1097/00002820-199610000-00004
  17. Kliucinskas M, Nadisauskiene RJ, Minkauskiene M. Prevalence and risk factors of HPV infection among high-risk rural and urban Lithuanian women. Gynecol Obstet Invest 2006;62(3):173-180. https://doi.org/10.1159/000093572
  18. Kornya L, Cseh I, Deak J, Bak M, Fulop V. The diagnostics and prevalence of genital human papillomavirus (HPV) infection in Hungary. Eur J Obstet Gynecol Reprod Biol 2002;100(2):231-236. https://doi.org/10.1016/S0301-2115(01)00474-2
  19. Kwasniewska A, Charzewska J, Tukendorf A, Semczuk M. Dietary factors in women with dysplasia colli uteri associated with human papillomavirus infection. Nutr Cancer 1998;30(1):39-45. https://doi.org/10.1080/01635589809514638
  20. Lowy DR, Schiller JT. Prophylactic human papillomavirus vaccines. J Clin Invest 2006;116(5):1167-1173. https://doi.org/10.1172/JCI28607
  21. Matsumoto K, Yasugi T, Oki A, Hoshiai H, Taketani Y, Kawana T, et al. Are smoking and chlamydial infection risk factors for CIN? Different results after adjustment for HPV DNA and antibodies. Br J Cancer 2003;89(5):831-833. https://doi.org/10.1038/sj.bjc.6601220
  22. Molano M, Posso H, Weiderpass E, van den Brule AJ, Ronderos M, Franceschi S, et al. Prevalence and determinants of HPV infection among Colombian women with normal cytology. Br J Cancer 2002;87(3):324-333. https://doi.org/10.1038/sj.bjc.6600442
  23. Moscicki AB, Shiboski S, Broering J, Powell K, Clayton L, Jay N, et al. The natural history of human papillomavirus infection as measured by repeated DNA testing in adolescent and young women. J Pediatr 1998;132(2):277-284. https://doi.org/10.1016/S0022-3476(98)70445-7
  24. Munoz N, Bosch FX, de Sanjose S, Herrero R, Castellsague X, Shah KV, et al. Epidemiologic classification of human papillomavirus types associated with cervical cancer. N Engl J Med 2003; 348(6):518-527. https://doi.org/10.1056/NEJMoa021641
  25. Nagata C, Shimizu H, Yoshikawa H, Noda K, Nozawa S, Yajima A, et al. Serum carotenoids and vitamins and risk of cervical dysplasia from a case-control study in Japan. Br J Cancer 1999;81(7):1234-1237. https://doi.org/10.1038/sj.bjc.6690834
  26. Oh JK, Franceschi S, Kim BK, Kim JY, Ju YH, Hong EK, et al. Prevalence of human papillomavirus and Chlamydia trachomatis infection among women attending cervical cancer screening inthe Republic of Korea. Eur J Cancer Prev 2009;18(1):56-61. https://doi.org/10.1097/CEJ.0b013e328305a0a6
  27. Pollack AE, Balkin M, Edouard L, Cutts F, Broutet N. Ensuring access to HPV vaccines through integrated services: a reproductive health perspective. Bull World Health Organ 2007;85(1):57-63. https://doi.org/10.2471/BLT.06.034397
  28. Rama CH, Roteli-Martins CM, Derchain SF, Longatto-Filho A, Gontijo RC, Sarian LO, et al. [Prevalence of genital HPV infection among women screened for cervical cancer]. Rev Saude Publica 2008;42(1):123-130. https://doi.org/10.1590/S0034-89102008000100016
  29. Richardson H, Abrahamowicz M, Tellier PP, Kelsall G, du Berger R, Ferenczy A, et al. Modifiable risk factors associated with clearance of type-specific cervical human papillomavirus infections in a cohort of university students. Cancer Epidemiol Biomarkers Prev 2005;14(5):1149-1156. https://doi.org/10.1158/1055-9965.EPI-04-0230
  30. Schiffman M, Kjaer SK. Chapter 2: Natural history of anogenital human papillomavirus infection and neoplasia. J Natl Cancer Inst Monogr 2003(31):14-19.
  31. Sedjo RL, Inserra P, Abrahamsen M, Harris RB, Roe DJ, Baldwin S, et al. Human papillomavirus persistence and nutrients involved in the methylation pathway among a cohort of young women. Cancer Epidemiol Biomarkers Prev 2002;11(4):353-359.
  32. Sedjo RL, Roe DJ, Abrahamsen M, Harris RB, Craft N, Baldwin S, et al. Vitamin A, carotenoids, and risk of persistent oncogenic human papillomavirus infection. Cancer Epidemiol Biomarkers Prev 2002;11(9):876-884.
  33. Shin HR, Franceschi S, Vaccarella S, Roh JW, Ju YH, Oh JK, et al. Prevalence and determinants of genital infection with papillomavirus, in female and male university students in Busan, South Korea. J Infect Dis 2004;190(3):468-476. https://doi.org/10.1086/421279
  34. Shin HR, Lee DH, Herrero R, Smith JS, Vaccarella S, Hong SH, et al. Prevalence of human papillomavirus infection in women in Busan, South Korea. Int J Cancer 2003;103(3):413-421. https://doi.org/10.1002/ijc.10825
  35. Tolstrup J,Munk C, Thomsen BL, Svare E, van den Brule AJ, Gronbaek M, et al. The role of smoking and alcohol intake in the development of high-grade squamous intraepithelial lesions among high-risk HPV-positive women. Acta Obstet Gynecol Scand 2006;85(9):1114-1119. https://doi.org/10.1080/00016340600677027
  36. Trottier H, Franco EL. The epidemiology of genital human papillomavirus infection. Vaccine 2006;24 Suppl 1:S1-15. https://doi.org/10.1016/j.vaccine.2005.07.047
  37. Vaccarella S, Herrero R, Snijders PJ, Dai M, Thomas JO, Hieu NT, et al. Smoking and human papillomavirus infection: pooled analysis of the International Agency for Research on Cancer HPV Prevalence Surveys. Int J Epidemiol 2008;37(3):536-546. https://doi.org/10.1093/ije/dyn033
  38. Walboomers JM, Jacobs MV, Manos MM, Bosch FX, Kummer JA, Shah KV, et al. Human papillomavirus is a necessary cause of invasive cervical cancer worldwide. J Pathol 1999;189(1):12-19. https://doi.org/10.1002/(SICI)1096-9896(199909)189:1<12::AID-PATH431>3.0.CO;2-F
  39. Wang SS, Schiffman M, Herrero R, Carreon J, Hildesheim A, Rodriguez AC, et al. Determinants of human papillomavirus 16 serological conversion and persistence in a population-based cohort of 10000 women in Costa Rica. Br J Cancer 2004;91(7):1269-1274. https://doi.org/10.1038/sj.bjc.6602088
  40. Winer RL, Lee SK, Hughes JP, Adam DE, Kiviat NB, Koutsky LA.Genital human papillomavirus infection: incidence and risk factors in a cohort of female university students. Am J Epidemiol 2003;157(3):218-226. https://doi.org/10.1093/aje/kwf180