Journal of Korean Traditional Oncology (대한암한의학회지)
- Volume 15 Issue 1
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- Pages.47-61
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- 2010
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- 1975-244X(pISSN)
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- 2765-4850(eISSN)
Effect of Allergen Removed Rhus Verniciflua Extract on Inhibition of Tumor Metastasis
알러젠 제거 옻나무 추출물이 종양 전이 억제에 미치는 영향
- Park, Jae-Hyun (Dept. of oriental Medicine Graduate School of Wonkwang University) ;
- Moon, Goo (Dept. of oriental Medicine Graduate School of Wonkwang University)
- Received : 2010.12.07
- Accepted : 2010.12.20
- Published : 2010.12.28
Abstract
Objective : The aim of this present study is to evaluate the inhibitory effect of allergen removed Rhus verniciflua (ARV) on Matrix Metalloproteinase-9 (MMP-9), Matrix Metalloproteinase-2 (MMP-2) which is considered to have a clinically important role in tumor metastasis. Methods : The inhibitory effects of standardized extract of ARV on the MMP-2, MMP-9 were investigated by spectrofluorometer while the inhibitory effects on the active MMP-2, pro MMP-2, pro MMP-9 were investigated by zymography. Antimetastatic effect of standardized extract of ARV was investigated in vitro on human fibrosarcoma cell (HT1080)'s invasion through Matrigel. Results : The standardized extract of ARV showed inhibitory effects on the active MMP-2 (IC50,