Journal of Korean Traditional Oncology (대한암한의학회지)

Korean Association of Traditional Oncology (대한암한의학회)
권호 표지

Anti-metastatic Activity of Water Extract of Samguikoeuitang via Enhancement of Natural Killer Cells

삼귀고의탕 물추출물의 자연살해세포 활성을 통한 항전이효과

  • Ko, Hyun-Suk (Cancer Preventive Material Development Research Center, College of Oriental Medicine, Kyunghee University) ;
  • Park, Moon-Nyeo (Cancer Preventive Material Development Research Center, College of Oriental Medicine, Kyunghee University) ;
  • Kim, Bong-Lee (Cancer Preventive Material Development Research Center, College of Oriental Medicine, Kyunghee University) ;
  • Yoon, Taek-Joon (Department of Food and Nutrition, Yuhan University) ;
  • Song, Hyo-Sook (Cancer Preventive Material Development Research Center, College of Oriental Medicine, Kyunghee University) ;
  • Cho, Sung-Yun (Cancer Preventive Material Development Research Center, College of Oriental Medicine, Kyunghee University) ;
  • Lee, Hyo-Jung (Cancer Preventive Material Development Research Center, College of Oriental Medicine, Kyunghee University) ;
  • Lee, Hyo-Jeong (Cancer Preventive Material Development Research Center, College of Oriental Medicine, Kyunghee University) ;
  • Jeong, Soo-Jin (Cancer Preventive Material Development Research Center, College of Oriental Medicine, Kyunghee University) ;
  • Lee, Eun-Ok (Cancer Preventive Material Development Research Center, College of Oriental Medicine, Kyunghee University) ;
  • Kim, Sung-Hoon (Cancer Preventive Material Development Research Center, College of Oriental Medicine, Kyunghee University)
  • 고현숙 (경희대학교 한의과대학 암예방연구개발센터) ;
  • 박문녀 (경희대학교 한의과대학 암예방연구개발센터) ;
  • 김봉이 (경희대학교 한의과대학 암예방연구개발센터) ;
  • 윤택준 (유한대학교 식품영양학과) ;
  • 송효숙 (경희대학교 한의과대학 암예방연구개발센터) ;
  • 조성윤 (경희대학교 한의과대학 암예방연구개발센터) ;
  • 이효정 (경희대학교 한의과대학 암예방연구개발센터) ;
  • 이효정 (경희대학교 한의과대학 암예방연구개발센터) ;
  • 정수진 (경희대학교 한의과대학 암예방연구개발센터) ;
  • 이은옥 (경희대학교 한의과대학 암예방연구개발센터) ;
  • 김성훈 (경희대학교 한의과대학 암예방연구개발센터)
  • Received : 2010.12.07
  • Accepted : 2010.12.23
  • Published : 2010.12.28
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Abstract

The anti-metastatic activity of water extract of Samguikoeuitang (WSGKE) consisting of Ginseng Radix, Angelicae Radix, Sophora flavescens and Coicis Semenwas examined. Ethanol extract of Samguikoeuitang (ESGKE) showed significant cytotoxicity against colon 26-M3.1 carcinoma cells, while WSGEK did not. However, WSGKE significantly increased the production of IL-6 and IL-12 in thioglycollate-induced macrophages from Balb/c mice, whereas ESGKE did not. WSGKE significantly increased natural killer (NK) cell cytotoxicity against effecter YAC-1 cells in an Effecter cells/Target ratio dependent manner. Also, WSGKE significantly suppressed lung metastasis after i.v. injection of colon26-M3.1 carcinoma cells. Inhibitory effect of WSGKE on lung metastasis totally abolished in NK cells-deficient mice by treatment with anti-asialo GM1 serum. In addition, the combination treatment of cisplatin and WSGKE (100 ${\mu}g$/mouse) prolonged the lifespan of mice inoculated by colon26-M3.1 cell. These findings suggest that WSGKE can inhibit lung metastasis and prolong life span via immunological enhancement as a Biological Response Modifier.

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