한국식생활문화학회지 (Journal of the Korean Society of Food Culture)

  • 제25권2호
  • /
  • Pages.232-239
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  • 2010
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  • 1225-7060(pISSN)
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  • 2288-7148(eISSN)
한국식생활문화학회 (Korean Society of Food Culture)
권호 표지
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노령 흰쥐의 대뇌 조직에서 알루미늄 투여에 대한 녹차 추출물이 인지질 함량에 미치는 효과

Effects of Green Tea Extract Diet on the Phospholipid Content of Aluminum-Induced-Damaged Cerebral Tissue of Old Rats

  • 정영희 (광주보건대학 식품영양학과) ;
  • 한성희 (원광보건대학 식품영양과)
  • Jung, Young-Hee (Department of Food of Nutrition Kwangiu Science College) ;
  • Han, Sung-Hee (Department of Food of Nutrition, Wonkwang Health Science College)
  • 투고 : 2009.11.20
  • 심사 : 2010.03.03
  • 발행 : 2010.04.30
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초록

This study was designed to investigate the effects of green tea extract on aluminum-induced damage to phospholipid content in old rat cerebral tissue. The aim of this study was to investigate the possibility that aluminum is the cause of Alzheimer's disease. Forty Sprague-Dawley old male rats weighing 350$\pm$10 g were divided into four groups, consisting of a control group (CON), 40 ppm aluminum sulfate group (Al-40), green tea water extract group (GTWE), and 40 ppm aluminum sulfate and green tea water extract groups (Al-40+GTWE) and kept on their respective diets for 12 weeks. In order to discover the influence of aluminum on cerebral tissue of old male rats, the serum aluminum concentration and phospholipid composition were compared between the aluminum-treated group and the normal group. The results showed that the serum aluminum concentration was higher in the aluminum sulfate-treated group than in the normal group. The cerebral tissue phospholipid concentration decreased significantly in the aluminum sulfate treated group as compared to the normal group. The results of this experiment show that increase of aluminum concentration in experimental animals causes the rise of serum aluminum and phospholipid concentrations, phenomena that are very similar to those shown in Alzheimer's disease., The results of this experiment, together with reports that aluminum is a cause of neurofibrillary tangles in cerebral tissue, therefore demonstrate the possibility that aluminum is the cause of Alzheimer's disease. Green tea water extract is also shown to be an effective therapeutic candidate for the treatment of Alzheimer's disease.

키워드

참고문헌

  1. Akeson MA, Munns DN, Buran RG. 1989. Absorption of Al+3 to phosphatidyl-choline versicles. Biochim Biophys Acta, 986(1):33-40 https://doi.org/10.1016/0005-2736(89)90269-1
  2. Bartus RY, Dean RLB. 1982. The cholinergic hypothesis of geriatric memory dysfunction. Science, 217(4558):408-416 https://doi.org/10.1126/science.7046051
  3. Baddely AD, Bressi S, Sala SD, Logie R, Soinnler H. 1991. The decline of working memory in Alzheimer's disease. Brain, 114(6):2521-2542 https://doi.org/10.1093/brain/114.6.2521
  4. Bergmeyer HU. 1995. Methods of enzymatic analysis, verlag chemie. Academic press weinheim, 1(1):20-28
  5. Berlyne GM, Yagil R, Weinberger G, Knopf E, Danovicth GM. 1972. Auminium toxicity in rats. Lancet, 299(7750):564-568 https://doi.org/10.1016/S0140-6736(72)90357-1
  6. Bierer LM, Haroutunian V, Gabriel S, Knott PJ, Carlin LS, Purohit DP, Perl DP, Perl D, Dchmeilder J, Kanof P, Davis KL. 1995. Neurochemical correlates of dementia sevenity in Alzheimer's disease; relative importance of the cholinergic deficients. J Neurochemistry, 64(2):749-760
  7. Blusztain JK, Gonzalez-coviella IL, Logue M, Growdon JH and Wurtman. RJ 1990. Levels of phosphlipid catabolic intermediates, glycerophosphocholine and glycerophosphoetanolamine are elevated in brains of Alzheimer's disease but not of Down's syndrome patients. Brain Res Bull, 17(1-2):240-244
  8. Borchelt AA, Thinakaren G, Eckman CB, Lee MK, Davenport F, Ratovitsky T, Prada CM, Kim G, Seekins S, Yager D, Slunt HH, Wang R, Younkin SG, Sisodia SS. 1996. Familiai alzheimer's disease-linked presenilin antagonizes scopolamine-induced deficients in a passive-avoidance task but not scopolamine-induced hypermotility in rats. Pharm Pharmacol, 45:841-843
  9. Bravo L. 1998. Polyphenol chemistry dietary sources metabolism and nutritional significance. Nutr rev, 56(11):317-333
  10. Bryan AA, Fraser SP, Suh YH, Djamgoz MB. 2000. Toxic effect of the beta-amyloid precursor protein C-terminus fragment and $Na^+/Ca^{2+}$ gradients. Neuroreport Oct, 11(15):3357-3360 https://doi.org/10.1097/00001756-200010200-00019
  11. Candy JM, Oakley AE, Klinowski J, Carpenter TA, Perry RH, Atack JR, Perry EK, Blessed G, Fairbairn A, Edwardson JA. 1986. Aluminosilicates and senile plaque formation in Alzheimer's disease. Lancet, 15(1):354-357
  12. Choi SI, Lee JH, Lee SR. 1994. Effects of green tea beverage on the removal of cadium and lead by animal experiments. Korean J Food Sci Technol, 26(6):740-744
  13. Chan YM, Wong R, Maclean L. 1983. Epidemiologic health study of workers in an aluminum smelter in British columbia, Effects on the respiratory system. Am Rev Respir Dis, 127(4):465-469 https://doi.org/10.1164/arrd.1983.127.4.465
  14. Chang NS, Ryu SM. 2001. Antioxidative effects of green tea powder diet against ethanol-induced oxidative damage in rat brain regions. Korea J Nutr, 34(5):525-531
  15. Cheon YM, Chang YK, Baik TK. 1999. Evidence of memory improvement by phosphatidylcholine supplement at fetus and neonate. Kor J Nutr, 32(8):864-869
  16. Choe JH, Chang NS. 2002. Effects of green tea powder or antioxidant vitamin supplementation on lipid peroxidation and antioxidant enzyme activities in 9 month-and 12 month-old rat brain regions. Korean J Nutr, 35(4):431-438
  17. Choi SI, Lee JH, Lee SR. 1994. Effect of green tea beverage on the removal of cadimium and lead by animal experiments. Korean J Food Sci Technol, 26(6):740-744
  18. Cho YJ, Ahn BJ, Choi C. 1993. Inhibition effect of against angiotensin converting enzyme of flavan-3-oils isolated korean green tea. Korean J Food Sci Technol, 25(3):238-242
  19. Chung HC, Yoo YS. 1995. Effects of aqueous green tea extracts with a tocopherol and lection on the lipid metabolism in serum and liver of rats. Korean J Nutr, 28:(1) 15-22
  20. Croos CE, Halliwell B, Borish ET, Pryor WA, Ames BN, Saul RA, McCord JM, Harman D. 1987. Oxygen radicals and human disease. Ann Intern Med, 107(4):526-545 https://doi.org/10.7326/0003-4819-107-4-526
  21. Davies P, Maloney AJ. 1976. Selective loss of central cholinergic neurons in Alzherimer's disease. Lancet, 25(2):1403-1405.
  22. Farber SA, Buyukuysal RL, Wurtman RJ. 1991. Why do phospholipid levels decrease with repated stimulation? A study of choline-containing compounds in rat striatum following electrical stimulation. Annal NY Acad, Sci, 640:114-117 https://doi.org/10.1111/j.1749-6632.1991.tb00201.x
  23. Folch J, Lees M, Sloane-Stanley G. 1957. A simple method for the isolation and purification of total lipids from animal tissue. J Biol Chem, 22(6):497-509
  24. Fujita Y, Tamane T, Tanaka M, Kuwata K, Okuzumi J, Takahashi T, Fujiki H, Okuzumi J, Takahashi T, Fujiki H, Okuda T. 1989. Inhibitory effect of (-)epigallocatechin gallate on carcinogenenesis with N-ethyl-N-nito-N-nitrosoguanidine in mouse duodenum. J Japan Cancer Association, 80(6):503-508 https://doi.org/10.1111/j.1349-7006.1989.tb01666.x
  25. Gillian F, Paul A, Simon W, Ghose B, Lejeune J, Corbett J, Prasher V, Blair J. 1990. Defective gallium transferrin binding in Alzheimer's disease and down syndrome; possible mechanism for accumulation of aluminium in brain. Lancet, 335(3):745-750
  26. Greger JL. 1992. Dietary and other sources of aluminum intake. Ciba Found symp, 169:26-35
  27. Hanras C, Perrin JL. 1991. Gram-scale preparative HPLC of phospholipids from soybean lecithins. JAOCS, 68(11):812
  28. Hayashi E, Hayashi M, Yamazoe H. 1990. Pharmacological action of tea extract on the central nervous system in mice. Oyo Yakuri, 40(3):351-359
  29. Hong JT, Ryu SR, Kim HJ, Lee JK, Lee SH, Kim DB, Yun YP, Ryu JH, Lee BM, Kim PY. 2000. Neuroprotective effect of green tea extract in experimental ischemia-reperfusion brain injury. Brain Res Bull, 53(6):743-749 https://doi.org/10.1016/S0361-9230(00)00348-8
  30. Jack R, Rabin PL, Mckinney TD. 1983-1984. Dialysis encephalpathy a review. Int J Psychiatry in Med, 13(4):309-326 https://doi.org/10.2190/C36R-6WGP-LCYU-9VRG
  31. Jin BS, Jeon MY. 1999. A comparison of depression and anxiety in Alzheimer's disease and vascular disease. J Korea Gerontol Soc, 19(2):47-57
  32. Jop RS. 1982. Effects of phosphatidyl choline administration to rat in blood and choline and acetylcholine in brain. J Pharmacol Exp Ther, 220(2):322-328
  33. Jope RS. 1982. Effects of phosphatidylcholine administration to rats on choline in blood and choline and acetylcholine in brain. J Pharmacology, 220(2):322-328
  34. Kim YI, Park JY, Choi SJ, Kim JK, Jeong CH, Choi SG, Lee SC, Choi SM, Heo HJ. 2008. Protective effect of green tea extract on amyloid $\beta$-peptide induced neurotoxicity. Korean J Food Presery, 15(5):743-748
  35. Kim HC. 2002. Assessment of clinical progression in Alzheimer's disease with special reference to global deterioration scale(GDS) and functional assessment staging. J Korean Soc Biol Ther Psychiatry, 8(2):354-366
  36. Klein GL. 1990. Nutritional aspects of aluminum toxicity. Nutrition reserach review, 3(1):117-141 https://doi.org/10.1079/NRR19900009
  37. Komatsu M, Hiramatsu M. 2000. The efficacy of an antioxidant cockatail on lipid peroxide level and superoxide dismutase activity in aged rat brain and DNA damage in iron-induced epileptogenic foci. Toxicol, 148(2):143-148 https://doi.org/10.1016/S0300-483X(00)00205-5
  38. Korea Institute for health and social affairs. The study on development of mapping in dementia management. 2007
  39. Last JM, Wallace RB, Connor EB, Fielding JE, Frank AL, Scutchfield FD, Tyler CW, Wenzel RP. 1998. Maxcy Rosenau-Last Public health & preventive medicine. Prenticehall international Inc, USA. 14:494-502
  40. Lee HS. 1992. Analysis of aluminium concentration in serum and phospholipid composition and catecholamine concentration in the brain of rats fed aluminium in drinking water. Dept. of food & nutrition graduate school Sook Myung women's university. pp. 27-33
  41. Lee SR, Suh SI, Kim SP. 2000. Protective effects of the green tea polyphenol (-)-epigallocatechin gallate against hippocampal neuronal damage after transient global ischemia in gerbils. Neurscience Letters, 287(3):191-194 https://doi.org/10.1016/S0304-3940(00)01159-9
  42. Lim JS. Studies on the treatment and prevention of dementia by green-tea extracts. 2004. Korea Med, 12(1):11-26
  43. Masak H, Atsumi T, Sakurai H. 1995. Detection of hydrogen peroxide hydroxy radicals in murine skin firoblasts under UVB irradiation. Biochem Biophys Res Commum, 206(2):474-479 https://doi.org/10.1006/bbrc.1995.1067
  44. Monitine TJ, Diana NM, Quinn JF, Beal MF, Markesbery WR, Roberts LJ, Morrow JD. 2002. Lipid peroxidation in aging brain and Alzheimer's disease. Free Radic Biol Med, 33(5):620-626 https://doi.org/10.1016/S0891-5849(02)00807-9
  45. Muramatsu K, Fukuro M, Hara Y. 1986. Effect of green tea catechins on plasma cholesterol level in cholesterol-fed rats. J Nutr Sci Vitaminol, 32(6):613-615 https://doi.org/10.3177/jnsv.32.613
  46. Oh MH, Houghton PJ, Whang WK, Cho JH. 2004. Screening of korean herbal medicines used to improve cognitive function for anti-cholinesterase activity. Phytomedicine, 11(9):544-548. https://doi.org/10.1016/j.phymed.2004.03.001
  47. Park CO, Jin SH, Ryu BH. 1996. Antioxidant activity of green tea extracts toward human low density lipoprotein. Koean J Food Sci Technol, 28(5):850-858
  48. Perry RH, Blessed G, Perry EK. 1980. Histochemical observations on cholinesterase activities on the brains of elderly normal and demented (Alzheimer-type) partients. Age-aging, 9(1):9-16 https://doi.org/10.1093/ageing/9.1.9
  49. Price DL. 1986. New perspective on Alzheimer's disease. Annu Rev Neurosci, 9(27):489-517 https://doi.org/10.1146/annurev.ne.09.030186.002421
  50. Reeves PG, Niselson FH, Fahey GC. 1993. AIN-93 purified diets for laboratory rodents finial report of the American institute of nutrition and hoc writing committee on the reformulation of the AIN-76A rodent diet. J Nutr, 123(11):1939-1995
  51. Rhi JW, Shin HS. 1993. Antioxidant effect of aqueous extract obtained from green tea. Korean J Food Sci Technol, 25(6):759-763
  52. Ryu BH, Park CO. 1997. Antioxidant effect of green tea extracts on enzymatic activities of hairless mice skin induce by ultraviolet B light. Korean J Food Sci Technol, 29(2):355-361
  53. Schulz V. 2003. Ginkgo extract or cholinersterase inhibitors in patients with dementia; what clinical trials and guidelines fail to considr. Phytomedicine, 10(4):74-79 https://doi.org/10.1078/1433-187X-00302
  54. Soliman KFA, Mazzio EA. 1998. In vitro attenuation of nitric oxide production in C6 strocyte cell culture by various dietary compounds. PSEBM 218(4):390-397
  55. Southorn PA, Powis G. 1988. Free radicals in medicine II. Involvement in human disease. Mayo Clin Proc, 63(4):390-408 https://doi.org/10.1016/S0025-6196(12)64862-9
  56. Suganuma M, Okabe S Sueoka E, Matsuyma S, Imai K, Nakachi K, Fujiki H. 1999. Green tea and cancer chemoprevention. Mutat Res, 428(1):339-344 https://doi.org/10.1016/S1383-5742(99)00059-9
  57. Tanizawa H, Toda Sazuka Y, Taniyama T, Hayashi T, Arich S and Takino Y. 1984. Natural antioxidants I. Antioxidative compounds of tea leaf. Chem Pharm Bull, 32(5):2011-2019 https://doi.org/10.1248/cpb.32.2011
  58. Yeo SG, Ahn CW, Kim JS, Park YB, Park YH, Kim SB. 1995. Antimicrobial effect of tea extracts from green tea, oolong tea and black tea. J Korean Soc Food Nutr, 24(2):293-298
  59. Yoon YH, Lee SJ. 1994. Effects of korean green tea, oolong tea and black tea beverage on the antioxidative detoxieation in rat poisoned with cadium. Korean J Nutr, 27(10):1007-1017
  60. Yu BP. 1993. Oxidative damage by free radicals and lipid peroxidative in aging. In Free Radicals in Aging. CRC Press, Boca Raton, pp. 57-88
  61. Woo JI, Lee JH, Yoo KY, Hong JP, Kim CY, Kim YL, Lee KW. 1997. Prevalence of dementia in the elderly residents of a rural community in korea. J Korean Neuropsychiatr Assoc, 36(1):92-101