Journal of the Korean Society of Food Culture (한국식생활문화학회지)

Korean Society of Food Culture (한국식생활문화학회)
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Effects of Green Tea Extract Diet on the Phospholipid Content of Aluminum-Induced-Damaged Cerebral Tissue of Old Rats

노령 흰쥐의 대뇌 조직에서 알루미늄 투여에 대한 녹차 추출물이 인지질 함량에 미치는 효과

  • Jung, Young-Hee (Department of Food of Nutrition Kwangiu Science College) ;
  • Han, Sung-Hee (Department of Food of Nutrition, Wonkwang Health Science College)
  • 정영희 (광주보건대학 식품영양학과) ;
  • 한성희 (원광보건대학 식품영양과)
  • Received : 2009.11.20
  • Accepted : 2010.03.03
  • Published : 2010.04.30
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Abstract

This study was designed to investigate the effects of green tea extract on aluminum-induced damage to phospholipid content in old rat cerebral tissue. The aim of this study was to investigate the possibility that aluminum is the cause of Alzheimer's disease. Forty Sprague-Dawley old male rats weighing 350$\pm$10 g were divided into four groups, consisting of a control group (CON), 40 ppm aluminum sulfate group (Al-40), green tea water extract group (GTWE), and 40 ppm aluminum sulfate and green tea water extract groups (Al-40+GTWE) and kept on their respective diets for 12 weeks. In order to discover the influence of aluminum on cerebral tissue of old male rats, the serum aluminum concentration and phospholipid composition were compared between the aluminum-treated group and the normal group. The results showed that the serum aluminum concentration was higher in the aluminum sulfate-treated group than in the normal group. The cerebral tissue phospholipid concentration decreased significantly in the aluminum sulfate treated group as compared to the normal group. The results of this experiment show that increase of aluminum concentration in experimental animals causes the rise of serum aluminum and phospholipid concentrations, phenomena that are very similar to those shown in Alzheimer's disease., The results of this experiment, together with reports that aluminum is a cause of neurofibrillary tangles in cerebral tissue, therefore demonstrate the possibility that aluminum is the cause of Alzheimer's disease. Green tea water extract is also shown to be an effective therapeutic candidate for the treatment of Alzheimer's disease.

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