Environmental Analysis Health and Toxicology

환경독성보건학회 (The Korean Society of Environmental Health and Toxicology)
권호 표지

은나노 입자의 입경 크기 및 형태에 따른 체내 동태 및 염증 반응

Comparison of Distribution and Inflammatory Response by Diameter and Shape of Silver Nanoparticles

  • 김수남 (한국화학연구원 부설 안전성평가연구소 정읍분소 흡입독성시험연구센터) ;
  • 노진규 (광운대학교 공과대학 화학공학과) ;
  • 강민성 (한국화학연구원 부설 안전성평가연구소 정읍분소 흡입독성시험연구센터) ;
  • 한영아 (한국화학연구원 부설 안전성평가연구소 정읍분소 흡입독성시험연구센터) ;
  • 이병석 (한국화학연구원 부설 안전성평가연구소 대전본소 독성병리부) ;
  • 김영훈 (광운대학교 공과대학 화학공학과) ;
  • 박광식 (동덕여자대학교 약학대학 예방약학교실) ;
  • 최경희 (국립환경과학원 환경건강연구부 위해성평가연구과) ;
  • 박은정 (국립환경과학원 환경건강연구부 위해성평가연구과)
  • Kim, Soo-Nam (Inhalation Toxicology Center, KIT Jeongeup Campus) ;
  • Roh, Jin-Kyu (Department of Chemical Engineering, Kwangwoon University) ;
  • Kang, Min-Sung (Inhalation Toxicology Center, KIT Jeongeup Campus) ;
  • Han, Young-Ah (Inhalation Toxicology Center, KIT Jeongeup Campus) ;
  • Lee, Byoung-Seok (Division of Toxicologic Pathology, Korea Institute of Toxicology) ;
  • Kim, Young-Hun (Department of Chemical Engineering, Kwangwoon University) ;
  • Park, Kwang-Sik (College of Pharmacy, Dongduk Women's University) ;
  • Choi, Kyung-Hee (Department of Risk Assessment, National Institute of Environmental Research) ;
  • Park, Eun-Jung (Department of Risk Assessment, National Institute of Environmental Research)
  • 투고 : 2010.04.22
  • 심사 : 2010.09.02
  • 발행 : 2010.09.30
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초록

The market size of engineered nanoparticles is rapidly increasing due to the fast application of nanotechnologies into different industries and consumer products. The development of new technology and materials has improved human's quality of life, but it also entails the possibility of exposure to new materials. In this study, we compared the distribution in the body by the inflow of silver nanoparticles having another diameter and shape at 1 h or 24 h after injection via the tail vein. And, we compared the cell composition and cytokine concentration in BAL fluid, and histopathological changes. As results, discharge of silver nanoparticles having small diameter and sphere shape was more rapid than that of big diameter or plate shape. It is estimated that the toxicity in liver and lung was proportional to accumulation level. The persistence of inflammation was also longer in mice treated with plate shape. Consequently, we suggest that the first choice of silver nanoparticles having small diameter and sphere shape in applying is desirable.

키워드

참고문헌

  1. Drake PL and Hazelwood KJ. Exposure-related health effects of silver and silver compounds: a review, Ann Occup Hyg 2005; 49(7): 575-585. https://doi.org/10.1093/annhyg/mei019
  2. http://www.nanotechproject.org/inventories/consumer, 2010. 05.22
  3. Ju-Nam Y and Lead JR. Manufactured nanoparticles: an overview of their chemistry, interactions and potential environmental implications, Sci Total Environ 2008; 400(1-3): 396-414. https://doi.org/10.1016/j.scitotenv.2008.06.042
  4. Kim YS, Kim JS, Cho HS, Rha DS, Kim JM, Park JD, Choi BS, Lim R, Chang HK, Chung YH, Kwon IH, Jeong J, Han BS and Yu IJ. Twenty-eight-day oral toxicity, genotoicity, and gender-related tissue distribution of silver nanoparticles in Sprague-Dawley rats, Inhal Toxicol 2008; 20(6): 575-583. https://doi.org/10.1080/08958370701874663
  5. Limbach LK, Wick P, Manser P, Grass RN, Bruinink A and Stark WJ. Exposure of engineered nanoparticles to human lung epithelial cells: influence of chemical composition and catalytic activity on oxidative stress, Environ Sci Technol 2007; 41(11): 4158-4163. https://doi.org/10.1021/es062629t
  6. Lubick N. Nanosilver toxicity: ions, nanoparticles-or both?, Environ Sci Technol 2008; 42(23): 8617. https://doi.org/10.1021/es8026314
  7. Luoma SN. Silver nanotechnologies and the environment: old problems or new challenges? The Pew Charitable Trusts and the Woodrow Wilson International Center for Scholars: Washington DC; 2008.
  8. Oberdorste G, Maynard A, Donaldson K, Castranova V, Fitzpatrick J, Ausman K, Carter J, Karn B, Kreyling W, Lai D, Olin S, Monteiro-Riviere N, Warheit D and Yang H. Principles for characterizing the potential human health effects from exposure to nanomaterials: elements of a screening strategy, Part Fibre Toxicol 2005; 2: 8. https://doi.org/10.1186/1743-8977-2-8
  9. Park EJ, Park YK and Park K. Acute toxicity and tissue distribution of cerium oxide nanoparticles by a single oral administration in rats, Toxicol Res 2009a; 25(2): 79-84. https://doi.org/10.5487/TR.2009.25.2.079
  10. Park EJ, Cho WS, Jeong J, Yi J, Choi K and Park K. Proinflammatory and potential allergic responses resulting from B cell activation in mice treated with multi-walled carbon nanotubes by intratracheal instillation, Toxicology 2009b; 259(3): 113-121. https://doi.org/10.1016/j.tox.2009.02.009
  11. Park EJ, Kim H, Kim Y, Yi J, Choi K and Park K. Carbon fullerenes (C60s) can induce inflammatory responses in the lung of mice, Toxicol Appl Pharmacol 2010a; 244(2): 226-233. https://doi.org/10.1016/j.taap.2009.12.036
  12. Park EJ, Yi J, Kim Y, Choi K and Park K. Silver nanoparticles induce cytotoxicity by a Trojan-horse type mechanism, Toxicol In Vitro 2010b; 24(3): 872-878. https://doi.org/10.1016/j.tiv.2009.12.001
  13. Snopczynski T, Goralczyk K, Czaja K, Strucinski P, Hernik A, Korcz W and Ludwicki JK. Nanotechnology-possibilities and hazards, Rocz Panstw Zakl Hig 2009; 60(2): 101-111.
  14. Swidwinska-Gajewska AM. Nanoparticles (part 2)-advantages and health risk, Med Pr 2007; 58(3): 253-263.
  15. Thrall L. A nano Trojan horse, Environ Sci Technol 2007; 41(11): 3791-3792.