대한기관식도과학회지 (Korean Journal of Bronchoesophagology)
- 제16권2호
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- Pages.83-90
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- 2010
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- 1226-0916(pISSN)
위식도역류질환과 인후두역류질환의 대한 최신지견
Update of Pathophysiology in GERO/LPR
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우정수
(고려대학교 의과대학 이비인후-두경부외과학교실)
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Woo, Jeong-Sao
(Department of Otolaryngology-Head & Neck Surgery, College of Medicine, Korea University)
- 투고 : 2010.11.29
- 심사 : 2010.12.11
- 발행 : 2010.12.30
초록
The pathophysiology of Gastroesophageal reflux disease (GERD) has been known that it is developed when the offense-primarily the gastric acid-pepsin content of the refluxate-overcomes a 3-tiered esophageal protective defense. consisting of antireflux mechanisms, luminal clearance mechanisms, and tissue resistance. Laryngopharyngeal reflux (LPR), which is known as an extraesophageal variant of GERD, has been considered to be developed by transient lower esophageal sphincter relaxation (TLESR), direct mucosal injury by gastric contents, more sensitive mucosa compared to esophagus, and absence of buffering effect and aggravation of the injury due to pepsin. However, hypothesis of the pathophysiology in both entities are numerous and still lack of understanding for being a theory. There is no conflict that understanding the pathophysiology is necessary for resolving the problems of these diseases and numerous studies and results have been releasing. This review could provide clinicians dealing with GERD and LPR with applicable new information and help for overcoming the clinical obstruction.