Journal of Korean Neurosurgical Society

The Korean Neurosurgical Society (대한신경외과학회)
권호 표지
DOI QR코드

DOI QR Code

Juvenile Pilomyxoid Astrocytoma in the Opticohypothalamus

  • Kim, Sung-Hyun (Department of Neurosurgery, Chonnam National University Hwasun Hospital and Medical School) ;
  • Kang, Sam-Suk (Department of Neurosurgery, Chonnam National University Hwasun Hospital and Medical School) ;
  • Jung, Tae-Young (Department of Neurosurgery, Chonnam National University Hwasun Hospital and Medical School) ;
  • Jung, Shin (Department of Neurosurgery, Chonnam National University Hwasun Hospital and Medical School)
  • Received : 2009.05.20
  • Accepted : 2010.11.22
  • Published : 2010.11.28
Download PDF
⟨ Previous Next ⟩

Abstract

Pilomyxoid astrocytoma (PMA) is a newly recognized variant of a pilocytic astrocytoma. This report describes a case of a pilomyxoid astrocytoma that occurred in the opticohypothalamus. The patient was a 18-year-old girl who complained decreased visual acuity and visual field over a period of two years. Magnetic resonance imaging (MRI) showed an irregular lobulated tumor with heterogeneous enhancement at the suprasellar region involving the hypothalamus. The mass was partially removed via the subfrontal approach. Its pathology was confirmed to be PMA. Adjuvant chemotherapy with cisplatin and vincristine was started following tumor resection. After four cycles, the mass showed a partial response to the chemotherapy. Although long-term outcome is yet to be determined, the administration of combined cisplatin and vincristine treatment seems to be an effective regimen for a pilomyxoid astrocytoma.

Keywords

References

  1. Brown MT, Friedman HS, Oakes WJ, Boyko OB, Hockenberger B, Schold SC Jr : Chemotherapy for pilocytic astrocytomas. Cancer 71 : 3165-3172, 1993 https://doi.org/10.1002/1097-0142(19930515)71:10<3165::AID-CNCR2820711044>3.0.CO;2-N
  2. Burger PC, Cohen KJ, Rosenblum MK, Tihan T : Pathology of diencephalic astrocytomas. Pediatr Neurosurg 32 : 214-219, 2000 https://doi.org/10.1159/000028937
  3. Fernandez C, Figarella-Branger D, Girard N, Bouvier-Labit C, Gouvernet J, Paz Paredes A, et al. : Pilocytic astrocytomas in children : prognostic factors-a retrospective study of 80 cases. Neurosurgery 53 : 544-553; discussion 554-555, 2003 https://doi.org/10.1227/01.NEU.0000079330.01541.6E
  4. Fuller CE, Frankel B, Smith M, Rodziewitz G, Landas SK, Caruso R, et al. : Suprasellar monomorphous pilomyxoid neoplasm : an ultrastructural analysis. Clin Neuropathol 20 : 256-262, 2001
  5. Giannini C, Scheithauer BW, Burger PC, Christensen MR, Wollan PC, Sebo TJ, et al. : Cellular proliferation in pilocytic and diffuse astrocytomas. J Neuropathol Exp Neurol 58 : 46-53, 1999 https://doi.org/10.1097/00005072-199901000-00006
  6. Gjerris F, Klinken L : Long-term prognosis in children with benign cerebellar astrocytoma. Case report. J Neurosurg 49 : 179-184, 1978 https://doi.org/10.3171/jns.1978.49.2.0179
  7. Gottfried ON, Fults DW, Townsend JJ, Couldwell WT : Spontaneous hemorrhage associated with a pilomyxoid astrocytoma. Case Report. J Neurosurg 99 : 416-420, 2003 https://doi.org/10.3171/jns.2003.99.2.0416
  8. Kato T, Sawamura Y, Tada M, Ikeda J, Ishii N, Abe H : Cisplatin/ Vincristine chemotherapy for hypothalamic/visual pathway astrocytoma in young children. J Neurooncol 37 : 263-270, 1998 https://doi.org/10.1023/A:1005866021835
  9. Komotar RJ, Burger PC, Carson BS, Brem H, Olivi A, Goldthwaite PT, et al. : Pilocytic and pilomyxoid hypothalamic/chiasmatic astrocytomas. Neurosurgery 54 : 72-79; discussion 79-80, 2004 https://doi.org/10.1227/01.NEU.0000097266.89676.25
  10. Komotar RJ, Mocco J, Zacharia BE, Wilson DA, Kim PY, Canoll PD, et al. : Astrocytoma with pilomyxoid features presenting in an adult. Neuropathology 26 : 89-93, 2006 https://doi.org/10.1111/j.1440-1789.2006.00641.x
  11. Laithier V, Grill J, Le Deley MC, Ruchoux MM, Couanet D, Doz F, et al. : Progression-free survival in children with optic pathway tumors--dependence on age and the quality of the response to chemotherapyresults of the first French prospective study for the French Society of Pediatric Oncology. J Clin Oncol 21 : 4572-4578, 2003 https://doi.org/10.1200/JCO.2003.03.043
  12. Linscott LL, Osborn AG, Blaser S, Castillo M, Hewlett RH, Wieselthaler N, et al. : Pilomyxoid astrocytoma: expanding the imaging spectrum. AJNR Am J Neuroradiol 29 : 1861-1866, 2008 https://doi.org/10.3174/ajnr.A1233
  13. Tihan T, Fisher PG, Kepner JL, Godfraind C, McComb RD, Goldthwaite PT, et al. : Pediatric astrocytomas with monomorphous pilomyxoid features and a less favorable outcome. J Neuropathol Exp Neurol 58 : 1061-1068, 1999 https://doi.org/10.1097/00005072-199910000-00004
  14. Tsugu H, Oshiro S, Yanai F, Komatsu F, Abe H, Fukushima T, et al. : Management of pilomyxoid astrocytomas: our experience. Anticancer Res 29 : 919-926, 2009

Cited by

  1. Pilomyxoid astrocytoma with high proliferation index vol.8, pp.3, 2013, https://doi.org/10.4103/1817-1745.123694
  2. Cystic pilomyxoid astrocytoma on suprasellar region in 7-year-old girl: Treatment and strategy vol.10, pp.2, 2010, https://doi.org/10.4103/1793-5482.154989