Bulletin of the Korean Chemical Society

Korean Chemical Society (대한화학회)
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Synthesis of Benzoxazole Amides as Novel Antifungal Agents against Malassezia Furfur

  • Kim, Beom-Joon (Department of Dermatology, Chung-Ang University College of Medicine) ;
  • Kim, Jin-Ah (School of Pharmacy, Ewha Womans University) ;
  • Kim, Young-Kook (Immun Regulater Research Center, Korea Research Institute of Bioscience & Biotechnology(KRIBB)) ;
  • Choi, Soon-Yong (Department of Biotechnology, College of Life Science & Nanotechnology, Hannam University) ;
  • ParkChoo, Hea-Young (School of Pharmacy, Ewha Womans University)
  • Received : 2009.12.30
  • Accepted : 2010.03.12
  • Published : 2010.05.20
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Abstract

Malassezia is a pathogenic fungus that causes skin diseases, such as tinea versicolor, atopic dermatitis and fatal sepsis. We report the synthesis of a series of benzoxazole amides and evaluation of their antifungal activity against Malassezia furfur. Twelve benzoxazole amides were prepared through the cyclization of the substituted 2-hydroxy aniline with N-(bis-methylsulfanylmethylene) amides. Among the prepared compounds, the compounds 4a, 8b, 8c and 8d showed in vitro antifungal activity.

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References

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